Journal of Autism and Developmental Disorders

, Volume 41, Issue 4, pp 427–433

Relation of Melatonin to Sleep Architecture in Children with Autism

Authors

  • Roberta M. Leu
    • Sleep Disorders Division, Department of NeurologyVanderbilt University School of Medicine
  • Liya Beyderman
    • Sleep Disorders Division, Department of NeurologyVanderbilt University School of Medicine
  • Emmanuel J. Botzolakis
    • Medical Scientist Training ProgramVanderbilt University School of Medicine
  • Kyla Surdyka
    • Sleep Disorders Division, Department of NeurologyVanderbilt University School of Medicine
  • Lily Wang
    • Department of BiostatisticsVanderbilt University School of Medicine
    • Sleep Disorders Division, Department of NeurologyVanderbilt University School of Medicine
    • Vanderbilt Kennedy Center for Human DevelopmentVanderbilt University
Original Paper

DOI: 10.1007/s10803-010-1072-1

Cite this article as:
Leu, R.M., Beyderman, L., Botzolakis, E.J. et al. J Autism Dev Disord (2011) 41: 427. doi:10.1007/s10803-010-1072-1

Abstract

Children with autism often suffer from sleep disturbances, and compared to age-matched controls, have decreased melatonin levels, as indicated by urine levels of the primary melatonin metabolite, 6-sulfatoxymelatonin (6-SM). We therefore investigated the relationship between 6-SM levels and sleep architecture in children with autism spectrum disorders (ASD). Twenty-three children, aged 4–10 years, completed two nights of polysomnography and one overnight urine collection for measurement of urinary 6-SM excretion rate. Parents completed the Children’s Sleep Habits Questionnaire. We found that higher urinary 6-SM excretion rates were associated with increased N3 sleep, decreased N2 sleep, and decreased daytime sleepiness. The results warrant further examination to examine the effects of supplemental melatonin on sleep architecture and daytime sleepiness.

Keywords

6-Sulfatoxymelatonin6-SMSleep stagesChildren’s Sleep Habits QuestionnaireParental Concerns QuestionnairePolysomnography

Copyright information

© Springer Science+Business Media, LLC 2010