Journal of Autism and Developmental Disorders

, Volume 40, Issue 2, pp 238–245

Antenatal Ultrasound and Risk of Autism Spectrum Disorders


    • Environmental Health Investigations BranchCalifornia Department of Public Health
  • Sherian Xu Li
    • Division of ResearchKaiser Permanente of Northern California
  • Cathleen K. Yoshida
    • Division of ResearchKaiser Permanente of Northern California
  • Lisa A. Croen
    • Division of ResearchKaiser Permanente of Northern California
Original Paper

DOI: 10.1007/s10803-009-0859-4

Cite this article as:
Grether, J.K., Li, S.X., Yoshida, C.K. et al. J Autism Dev Disord (2010) 40: 238. doi:10.1007/s10803-009-0859-4


We evaluated antenatal ultrasound (U/S) exposure as a risk factor for autism spectrum disorders (ASD), comparing affected singleton children and control children born 1995–1999 and enrolled in the Kaiser Permanente health care system. Among children with ASD (n = 362) and controls (n = 393), 13% had no antenatal exposure to U/S examinations; case–control differences in number of exposures during the entire gestation or by trimester were small and not statistically significant. In analyses adjusted for covariates, cases were generally similar to controls with regard to the number of U/S scans throughout gestation and during each trimester. This study indicates that antenatal U/S is unlikely to increase the risk of ASD, although studies examining ASD subgroups remain to be conducted.


Antenatal ultrasoundObstetrical ultrasoundAutism

Copyright information

© Springer Science+Business Media, LLC 2009