Journal of Autism and Developmental Disorders

, 39:1568

Quantitative Architectural Analysis: A New Approach to Cortical Mapping

  • Axel Schleicher
  • Patricia Morosan
  • Katrin Amunts
  • Karl Zilles
Original Paper

DOI: 10.1007/s10803-009-0790-8

Cite this article as:
Schleicher, A., Morosan, P., Amunts, K. et al. J Autism Dev Disord (2009) 39: 1568. doi:10.1007/s10803-009-0790-8

Abstract

Results from functional imaging studies are often still interpreted using the classical architectonic brain maps of Brodmann and his successors. One obvious weakness in traditional, architectural mapping is the subjective nature of localizing borders between cortical areas by means of a purely visual, microscopical examination of histological specimens. To overcome this limitation, objective mapping procedures based on quantitative cytoarchitecture have been generated. As a result, new maps for various species including man were established. In our contribution, principles of quantitative cytoarchitecture and algorithm-based cortical mapping are described for a cytoarchitectural parcellation of the human auditory cortex. Defining cortical borders based on quantified changes in cortical lamination is the decisive step towards a novel, highly improved probabilistic brain atlas.

Keywords

CytoarchitectureGray level indexCortical areaBorder detectionBrain mapping

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Axel Schleicher
    • 1
  • Patricia Morosan
    • 2
  • Katrin Amunts
    • 2
    • 3
    • 4
  • Karl Zilles
    • 1
    • 4
    • 5
  1. 1.C. and O. Vogt Institute of Brain ResearchDuesseldorf UniversityDüsseldorfGermany
  2. 2.Institute of Neuroscience and Medicine, INM-1Research Centre JuelichJuelichGermany
  3. 3.Department of Psychiatry and PsychotherapyRWTH Aachen UniversityAachenGermany
  4. 4.Juelich-Aachen Research Alliance (JARA)RWTH Aachen UniversityAachenGermany
  5. 5.Institute of Neuroscience and Medicine, INM-2Research Centre JuelichJuelichGermany