Original Paper

Journal of Autism and Developmental Disorders

, 39:1568

First online:

Quantitative Architectural Analysis: A New Approach to Cortical Mapping

  • Axel SchleicherAffiliated withC. and O. Vogt Institute of Brain Research, Duesseldorf University Email author 
  • , Patricia MorosanAffiliated withInstitute of Neuroscience and Medicine, INM-1, Research Centre Juelich
  • , Katrin AmuntsAffiliated withInstitute of Neuroscience and Medicine, INM-1, Research Centre JuelichDepartment of Psychiatry and Psychotherapy, RWTH Aachen UniversityJuelich-Aachen Research Alliance (JARA), RWTH Aachen University
  • , Karl ZillesAffiliated withC. and O. Vogt Institute of Brain Research, Duesseldorf UniversityJuelich-Aachen Research Alliance (JARA), RWTH Aachen UniversityInstitute of Neuroscience and Medicine, INM-2, Research Centre Juelich

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Abstract

Results from functional imaging studies are often still interpreted using the classical architectonic brain maps of Brodmann and his successors. One obvious weakness in traditional, architectural mapping is the subjective nature of localizing borders between cortical areas by means of a purely visual, microscopical examination of histological specimens. To overcome this limitation, objective mapping procedures based on quantitative cytoarchitecture have been generated. As a result, new maps for various species including man were established. In our contribution, principles of quantitative cytoarchitecture and algorithm-based cortical mapping are described for a cytoarchitectural parcellation of the human auditory cortex. Defining cortical borders based on quantified changes in cortical lamination is the decisive step towards a novel, highly improved probabilistic brain atlas.

Keywords

Cytoarchitecture Gray level index Cortical area Border detection Brain mapping