Original Paper

Journal of Autism and Developmental Disorders

, Volume 39, Issue 4, pp 572-588

First online:

The Prevalence and Phenomenology of Repetitive Behavior in Genetic Syndromes

  • Joanna MossAffiliated withCentre for Neurodevelopmental Disorders, School of Psychology, University of BirminghamDepartment of Psychology, Institute of Psychiatry, Kings College London
  • , Chris OliverAffiliated withCentre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham Email author 
  • , Kate ArronAffiliated withCentre for Neurodevelopmental Disorders, School of Psychology, University of Birmingham
  • , Cheryl BurbidgeAffiliated withCentre for Neurodevelopmental Disorders, School of Psychology, University of BirminghamDepartment of Psychology, Solihull NHS Trust
  • , Katy BergAffiliated withCentre for Neurodevelopmental Disorders, School of Psychology, University of BirminghamDepartment of Psychology, Royal Holloway, University of London

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Abstract

We investigated the prevalence and phenomenology of repetitive behavior in genetic syndromes to detail profiles of behavior. The Repetitive Behaviour Questionnaire (RBQ) provides fine-grained identification of repetitive behaviors. The RBQ was employed to examine repetitive behavior in Angelman (N = 104), Cornelia de Lange (N = 101), Cri-du-Chat (N = 58), Fragile X (N = 191), Prader-Willi (N = 189), Lowe (N = 56) and Smith-Magenis (N = 42) syndromes and individuals with intellectual disability of heterogeneous aetiology (N = 56). Repetitive behavior was variable across syndromes. Fragile X syndrome scored highly on all subscales. Angelman syndrome demonstrated a significantly lowered probability for most behaviors. Prader-Willi, Cri-du-Chat and Smith-Magenis syndrome evidenced unique profiles of repetitive behavior. There is extreme heterogeneity of repetitive behavior across genetic syndromes, highlighting syndrome specific profiles.

Keywords

Behavioral phenotype Autism spectrum disorder Repetitive behavior Compulsive behavior Stereotyped behavior