Journal of Autism and Developmental Disorders

, Volume 38, Issue 10, pp 1966–1975

Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism

  • S. Jill James
  • Stepan Melnyk
  • Stefanie Jernigan
  • Amanda Hubanks
  • Shannon Rose
  • David W. Gaylor
Original Paper

DOI: 10.1007/s10803-008-0591-5

Cite this article as:
Jill James, S., Melnyk, S., Jernigan, S. et al. J Autism Dev Disord (2008) 38: 1966. doi:10.1007/s10803-008-0591-5

Abstract

An integrated metabolic profile reflects the combined influence of genetic, epigenetic, and environmental factors that affect the candidate pathway of interest. Recent evidence suggests that some autistic children may have reduced detoxification capacity and may be under chronic oxidative stress. Based on reports of abnormal methionine and glutathione metabolism in autistic children, it was of interest to examine the same metabolic profile in the parents. The results indicated that parents share similar metabolic deficits in methylation capacity and glutathione-dependent antioxidant/detoxification capacity observed in many autistic children. Studies are underway to determine whether the abnormal profile in parents reflects linked genetic polymorphisms in these pathways or whether it simply reflects the chronic stress of coping with an autistic child.

Keywords

AutismHomocysteineGlutathioneDNA methylationParents

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • S. Jill James
    • 1
    • 2
  • Stepan Melnyk
    • 1
  • Stefanie Jernigan
    • 1
  • Amanda Hubanks
    • 1
  • Shannon Rose
    • 1
  • David W. Gaylor
    • 3
  1. 1.Department of PediatricsUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Arkansas Children’s Hospital Research InstituteLittle RockUSA
  3. 3.Department of BiostatisticsUniversity of Arkansas for Medical SciencesLittle RockUSA