Journal of Autism and Developmental Disorders

, Volume 38, Issue 8, pp 1581–1590

Brief Report: Methods for Acquiring Structural MRI Data in Very Young Children with Autism Without the Use of Sedation

  • Christine Wu Nordahl
  • Tony J. Simon
  • Cynthia Zierhut
  • Marjorie Solomon
  • Sally J. Rogers
  • David G. Amaral
Brief Report

DOI: 10.1007/s10803-007-0514-x

Cite this article as:
Nordahl, C.W., Simon, T.J., Zierhut, C. et al. J Autism Dev Disord (2008) 38: 1581. doi:10.1007/s10803-007-0514-x

Abstract

We describe a protocol with which we achieved a 93% success rate in acquiring high quality MRI scans without the use of sedation in 2.5–4.5 year old children with autism, developmental delays, and typical development. Our main strategy was to conduct MRIs during natural nocturnal sleep in the evenings after the child’s normal bedtime. Alternatively, with some older and higher functioning children, the MRI was conducted while the child was awake and watching a video. Both strategies relied heavily on the creation of a child and family friendly MRI environment and the involvement of parents as collaborators in the project. Scanning very young children with autism, typical development, and developmental delays without the use of sedation or anesthesia was possible in the majority of cases.

Keywords

MRIAutismNatural sleepSedationChildrenToddlers

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Christine Wu Nordahl
    • 1
  • Tony J. Simon
    • 2
  • Cynthia Zierhut
    • 3
  • Marjorie Solomon
    • 2
  • Sally J. Rogers
    • 2
  • David G. Amaral
    • 2
  1. 1.M.I.N.D. Institute and Department of Psychiatry and Behavioral SciencesUniversity of California at DavisSacramentoUSA
  2. 2.M.I.N.D. Institute and Department of Psychiatry and Behavioral SciencesUniversity of California at DavisSacramentoUSA
  3. 3.M.I.N.D. InstituteUniversity of California at DavisSacramentoUSA