Journal of Autism and Developmental Disorders

, Volume 38, Issue 2, pp 324–332

Are There Enhanced MBP Autoantibodies in Autism?

  • Jane E. Libbey
  • Hilary H. Coon
  • Nikki J. Kirkman
  • Thayne L. Sweeten
  • Judith N. Miller
  • Edward K. Stevenson
  • Janet E. Lainhart
  • William M. McMahon
  • Robert S. Fujinami
Original Paper

DOI: 10.1007/s10803-007-0400-6

Cite this article as:
Libbey, J.E., Coon, H.H., Kirkman, N.J. et al. J Autism Dev Disord (2008) 38: 324. doi:10.1007/s10803-007-0400-6

Abstract

Autoantibodies to central nervous system antigens, such as myelin basic protein (MBP), may play a role in autism. We measured autoantibody titers to MBP in children with autism, both classic onset and regressive onset forms, controls (healthy age- and gender-matched) and individuals with Tourette syndrome via enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to MBP, not accounted for by age or medication, between Tourette and classic autism (both significantly lower) when compared to regressive autism, but not when compared to controls. Autoantibody responses against MBP are unlikely to play a pathogenic role in autism.

Keywords

AutismTourette syndromeAutoantibodyMyelin basic proteinImmunoglobulin

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Jane E. Libbey
    • 1
  • Hilary H. Coon
    • 2
  • Nikki J. Kirkman
    • 1
  • Thayne L. Sweeten
    • 1
  • Judith N. Miller
    • 2
  • Edward K. Stevenson
    • 1
  • Janet E. Lainhart
    • 2
  • William M. McMahon
    • 2
  • Robert S. Fujinami
    • 1
  1. 1.Department of NeurologyUniversity of UtahSalt Lake CityUSA
  2. 2.Department of PsychiatryUniversity of UtahSalt Lake CityUSA