Brief Report: Abnormal Association Between the Thalamus and Brain Size in Asperger’s Disorder
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The objective of this study was to examine the relationship between thalamic volume and brain size in individuals with Asperger’s disorder (ASP). Volumetric measurements of the thalamus were performed on MRI scans obtained from 12 individuals with ASP (age range: 10–35 years) and 12 healthy controls (age range: 9–33 years). A positive correlation was found between total brain volume and thalamic size in controls, but not in ASP subjects. This occurred in the absence of differences in mean thalamic volumes between the study groups. Findings from this investigation point to an abnormal relationship between the thalamus and its projection areas in ASP and are consistent with similar studies in autism, supporting that these disorders are qualitatively similar and possibly quantitatively different.
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- Brief Report: Abnormal Association Between the Thalamus and Brain Size in Asperger’s Disorder
Journal of Autism and Developmental Disorders
Volume 38, Issue 2 , pp 390-394
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- Asperger’s disorder
- Brain size
- Industry Sectors
- Author Affiliations
- 1. Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
- 2. Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA, 94305, USA
- 3. Department of Psychiatry, College of Physicians and Surgeons, Columbia University, and New York State Psychiatric Institute, New York, NY, USA
- 4. Department of Psychiatry, Wayne State University, Detroit, MI, USA