Original Paper

Journal of Autism and Developmental Disorders

, Volume 38, Issue 1, pp 2-13

First online:

Offering to Share: How to Put Heads Together in Autism Neuroimaging

  • Matthew K. BelmonteAffiliated withDepartment of Human Development, Cornell University Email author 
  • , John C. MazziottaAffiliated withDepartment of Neurology, University of California Los Angeles
  • , Nancy J. MinshewAffiliated withDepartments of Psychiatry and Neurology, University of Pittsburgh
  • , Alan C. EvansAffiliated withMcConnell Brain Imaging Centre, Montreal Neurological Institute
  • , Eric CourchesneAffiliated withDepartment of Neurosciences, University of California San Diego
  • , Stephen R. DagerAffiliated withDepartment of Radiology, University of Washington
  • , Susan Y. BookheimerAffiliated withBrain Mapping Center, University of California Los Angeles
  • , Elizabeth H. AylwardAffiliated withDepartment of Radiology, University of Washington
  • , David G. AmaralAffiliated withMIND Institute, University of California Davis
    • , Rita M. CantorAffiliated withDepartment of Human Genetics, University of California Los Angeles
    • , Diane C. ChuganiAffiliated withDepartments of Pediatrics and Radiology, Children’s Hospital of Michigan
    • , Anders M. DaleAffiliated withDepartment of Neurosciences, University of California San Diego
    • , Christos DavatzikosAffiliated withDepartment of Radiology, University of Pennsylvania
    • , Guido GerigAffiliated withDepartment of Computer Science, University of North Carolina
    • , Martha R. HerbertAffiliated withDepartment of Neurology, Harvard Medical School
    • , Janet E. LainhartAffiliated withDepartment of Psychiatry, University of Utah
    • , Declan G. MurphyAffiliated withDepartment of Psychological Medicine, Institute of Psychiatry, King’s College London
    • , Joseph PivenAffiliated withDepartment of Psychiatry, University of North Carolina
    • , Allan L. ReissAffiliated withDepartment of Psychiatry and Behavioral Sciences, Stanford University
    • , Robert T. SchultzAffiliated withChild Study Center, Yale University
    • , Thomas A. ZeffiroAffiliated withNeural Systems Group, Massachusetts General Hospital
    • , Susan Levi-PearlAffiliated withTourette Syndrome Association
    • , Clara LajonchereAffiliated withAutism Genetic Resource Exchange
    • , Sophia A. ColamarinoAffiliated withCure Autism Now

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Abstract

Data sharing in autism neuroimaging presents scientific, technical, and social obstacles. We outline the desiderata for a data-sharing scheme that combines imaging with other measures of phenotype and with genetics, defines requirements for comparability of derived data and recommendations for raw data, outlines a core protocol including multispectral structural and diffusion-tensor imaging and optional extensions, provides for the collection of prospective, confound-free normative data, and extends sharing and collaborative development not only to data but to the analytical tools and methods applied to these data. A theme in these requirements is the need to preserve creative approaches and risk-taking within individual laboratories at the same time as common standards are provided for these laboratories to build on.

Keywords

Imaging MRI PET Morphometry Segmentation Data sharing