Journal of Autism and Developmental Disorders

, Volume 37, Issue 2, pp 210–217

MMR-Vaccine and Regression in Autism Spectrum Disorders: Negative Results Presented from Japan

Original Paper

DOI: 10.1007/s10803-006-0157-3

Cite this article as:
Uchiyama, T., Kurosawa, M. & Inaba, Y. J Autism Dev Disord (2007) 37: 210. doi:10.1007/s10803-006-0157-3


It has been suggested that the measles, mumps, and rubella vaccine (MMR) is a cause of regressive autism. As MMR was used in Japan only between 1989 and 1993, this time period affords a natural experiment to examine this hypothesis. Data on 904 patients with autism spectrum disorders (ASD) were analyzed. During the period of MMR usage no significant difference was found in the incidence of regression between MMR-vaccinated children and non-vaccinated children. Among the proportion and incidence of regression across the three MMR-program-related periods (before, during and after MMR usage), no significant difference was found between those who had received MMR and those who had not. Moreover, the incidence of regression did not change significantly across the three periods.



Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Tokio Uchiyama
    • 1
    • 2
  • Michiko Kurosawa
    • 3
  • Yutaka Inaba
    • 3
  1. 1.Department of Human WelfareOtsuma Women’s UniversityTama-city, TokyoJapan
  2. 2.Yokohama Psycho-developmental clinicYokohamaJapan
  3. 3.Department of Epidemiology and Environmental HealthJuntendo University School of MedicineTokyoJapan