An MRI Study of Minor Physical Anomalies in Autism
- First Online:
- Cite this article as:
- Hardan, A.Y., Keshavan, M.S., Sreedhar, S. et al. J Autism Dev Disord (2006) 36: 607. doi:10.1007/s10803-006-0103-4
The objective of this investigation was to examine the existence of minor physical anomalies (MPA) in autism. The interorbital and interlens distances were measured on MRI scans obtained from a sample of 40 non-mentally retarded individuals with autism and 41 healthy controls. No differences were observed between the two groups on any measurements. However, when the analysis was conducted using a split median procedure, individuals with autism and either low FSIQ, PIQ, or VIQ had shorter interorbital distances when compared to controls. Hypotelorism is a MPA that may be present in a subgroup of individuals with autism. Additional research is warranted using large sample sizes with a wide range of intellectual functioning.