Journal of Autism and Developmental Disorders

, Volume 36, Issue 5, pp 607–611

An MRI Study of Minor Physical Anomalies in Autism

  • Antonio Y. Hardan
  • Matcheri S. Keshavan
  • Sucheta Sreedhar
  • Mahduri Vemulapalli
  • Nancy J. Minshew
ORIGINAL PAPER

DOI: 10.1007/s10803-006-0103-4

Cite this article as:
Hardan, A.Y., Keshavan, M.S., Sreedhar, S. et al. J Autism Dev Disord (2006) 36: 607. doi:10.1007/s10803-006-0103-4

Abstract

The objective of this investigation was to examine the existence of minor physical anomalies (MPA) in autism. The interorbital and interlens distances were measured on MRI scans obtained from a sample of 40 non-mentally retarded individuals with autism and 41 healthy controls. No differences were observed between the two groups on any measurements. However, when the analysis was conducted using a split median procedure, individuals with autism and either low FSIQ, PIQ, or VIQ had shorter interorbital distances when compared to controls. Hypotelorism is a MPA that may be present in a subgroup of individuals with autism. Additional research is warranted using large sample sizes with a wide range of intellectual functioning.

Keywords

Physical anomalies MRI Autism Inter-orbit distance 

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Antonio Y. Hardan
    • 1
  • Matcheri S. Keshavan
    • 1
    • 2
  • Sucheta Sreedhar
    • 1
  • Mahduri Vemulapalli
    • 1
  • Nancy J. Minshew
    • 1
  1. 1.Western Psychiatric Institute and ClinicUniversity of Pittsburgh School of MedicinePittsburghUSA
  2. 2.Department of Psychiatry and Behavioral SciencesWayne State School of MedicineDetroitUSA
  3. 3.Department of Psychiatry and Behavioral SciencesStanford UniversityStanfordUSA