Hyperserotoninemia and Altered Immunity in Autism
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- Burgess, N.K., Sweeten, T.L., McMahon, W.M. et al. J Autism Dev Disord (2006) 36: 697. doi:10.1007/s10803-006-0100-7
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One of the most consistent biological findings in autism is elevated whole blood serotonin (5-HT) levels found in about 1/3 of cases. Immune abnormalities are also commonly observed in this disorder. Given 5-HT’s role as an immunomodulator, possible connections between 5-HT and immune abnormalities in autism are explored in this review. Areas of focus include hyperserotoninemia and cellular immune function, autoantibodies to 5-HT receptors, and 5-HT’s role in autoimmunity. Further research is needed to determine the interactions between neuropsychiatric and immune dysfunction in autism and related disorders.