Article

Journal of Autism and Developmental Disorders

, Volume 35, Issue 3, pp 377-385

Clinical Efficacy of Fluvoxamine and Functional Polymorphism in a Serotonin Transporter Gene on Childhood Autism

  • Yoko SugieAffiliated withDepartment of Pediatrics, Hamamatsu University School of MedicineDepartment of Pediatric Neurology, Hamamatsu City Medical Center for Developmental Medicine Email author 
  • , Hideo SugieAffiliated withDepartment of Pediatric Neurology, Hamamatsu City Medical Center for Developmental Medicine
  • , Tokiko FukudaAffiliated withDepartment of Pediatric Neurology, Hamamatsu City Medical Center for Developmental Medicine
  • , Masataka ItoAffiliated withDepartment of Pediatric Neurology, Hamamatsu City Medical Center for Developmental Medicine
  • , Yumiko SasadaAffiliated withDivision of Clinical Psychology, Hamamatsu City Medical Center for Developmental Medicine
  • , Mutsumi NakabayashiAffiliated withDivision of Clinical Psychology, Hamamatsu City Medical Center for Developmental Medicine
  • , Kazunobu FukashiroAffiliated withDivision of Clinical Psychology, Hamamatsu City Medical Center for Developmental Medicine
  • , Takehiko OhzekiAffiliated withDepartment of Pediatrics, Hamamatsu University School of Medicine

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Abstract

We studied the correlation between response to fluvoxamine and serotonin transporter gene promoter region polymorphism (5-HTTLPR). Eighteen children with autistic disorder completed a 12-week double-blind, placebo-controlled, randomized crossover study of fluvoxamine. Behavioral assessments were obtained before and at 12 weeks of treatment. 5-HTTLPR (long (l) or short(s)), was analyzed by the PCR method. Ten out of 18 patients responded to fluvoxamine treatment; allele type analysis revealed that clinical global effectiveness was noted significantly more in the l allele than in the s allele. However, with respect to language use, a significant effectiveness was noted in the s allele. 5-HTTLPR may influence the individual responses to fluvoxamine administration.

Keywords

Autistic disorder selective serotonin transporter inhibiter serotonin transporter gene 5-HTTLPR