International Ophthalmology

, Volume 35, Issue 3, pp 303–310

Optic neuritis in Hong Kong: a 1-year follow-up study

  • Patrick P. K. Lau
  • Gordon S. K. Yau
  • Jacky W. Y. Lee
  • Winnie W. Y. Wong
  • Victor T. Y. Tam
  • Eric Y. T. Chan
  • Doris M. W. Tse
  • Can Y. F. Yuen
Original Paper

DOI: 10.1007/s10792-014-9945-5

Cite this article as:
Lau, P.P.K., Yau, G.S.K., Lee, J.W.Y. et al. Int Ophthalmol (2015) 35: 303. doi:10.1007/s10792-014-9945-5

Abstract

To investigate the etiology and prevalence of optic neuritis in a Chinese population. This was a single centre prospective cohort study. Consecutive patients with either a first or recurrent attack of optic neuritis from November 2010 to December 2011 were recruited from a district hospital in Hong Kong Special Administrative Region, China. All patients underwent serology testing for NMO (neuromyelitis optica) IgG; oligoclonal bands from lumbar puncture; computer tomography and contrast magnetic resonance imaging (MRI) of the brain and orbit as well as visual field; and optical coherence tomography testing. Patients were followed up for 1 year after the initial attack. 30 optic neuritis subjects were recruited. 73.3 % (22/30) remain as clinical isolated syndrome (CIS) after 1-year follow-up. 10 % (3/30) patients developed multiple sclerosis. 10 % (3/30) were diagnosed with NMO and 6.7 % (2/30) with NMO-spectrum disorder. The majority of acute unilateral optic neuritis in Chinese was CIS in origin although a fraction does progress to develop MS or NMO-related disorders. Clinicians should be aware of the associations and offer appropriate systemic workups.

Keywords

Optic neuritisNeuromyelitis opticaMultiple sclerosisPrevalenceEtiology

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Patrick P. K. Lau
    • 1
  • Gordon S. K. Yau
    • 2
  • Jacky W. Y. Lee
    • 2
  • Winnie W. Y. Wong
    • 1
  • Victor T. Y. Tam
    • 2
  • Eric Y. T. Chan
    • 3
  • Doris M. W. Tse
    • 1
  • Can Y. F. Yuen
    • 2
  1. 1.Department of Medicine and GeriatricCaritas Medical CentreHong KongSpecial Administrative Region China
  2. 2.Department of OphthalmologyCaritas Medical Centre, Hong Kong Special Administrative RegionHong KongSpecial Administrative Region China
  3. 3.Department of ImmunologyQueen Mary HospitalHong KongSpecial Administrative Region China