International Ophthalmology

, Volume 31, Issue 2, pp 165–173

Adalimumab (Humira): a promising monoclonal anti-tumor necrosis factor alpha in ophthalmology

Authors

    • The Eye ClinicAzienda Ospedaliera Universitaria-Ospedali Riuniti di Ancona
    • Ophthalmology Section, The Neuroscience DepartmentPolytechnic University of Marche
    • Clinica OculisticaAzienda Ospedaliera Universitaria-Ospedali Riuniti di Ancona
  • Manuela Zucchi
    • The Dermatology ClinicAzienda Ospedaliera Universitaria-Ospedali Riuniti di Ancona
  • Pia Allegri
    • Uveitis Center, Ophthalmology DepartmentLavagna Hospital
  • Marta Lettieri
    • The Eye ClinicAzienda Ospedaliera Universitaria-Ospedali Riuniti di Ancona
    • Ophthalmology Section, The Neuroscience DepartmentPolytechnic University of Marche
  • Cesare Mariotti
    • The Eye ClinicAzienda Ospedaliera Universitaria-Ospedali Riuniti di Ancona
    • Ophthalmology Section, The Neuroscience DepartmentPolytechnic University of Marche
  • Alfonso Giovannini
    • The Eye ClinicAzienda Ospedaliera Universitaria-Ospedali Riuniti di Ancona
    • Ophthalmology Section, The Neuroscience DepartmentPolytechnic University of Marche
Review

DOI: 10.1007/s10792-011-9430-3

Cite this article as:
Neri, P., Zucchi, M., Allegri, P. et al. Int Ophthalmol (2011) 31: 165. doi:10.1007/s10792-011-9430-3

Abstract

Tumor necrosis factor alpha (TNF-α) is a key soluble mediator involved in the inflammatory cascade of many disorders including uveitis. Among the anti-TNF-α agents, one of the most used in immune-mediated diseases, such as inflammatory arthropathies, is adalimumab (Humira, Abbott Pharmaceutical Inc.), a fully humanized antibody. The purpose of this review is to analyze the main pharmacological and clinical aspects of adalimumab and its efficacy both in systemic and ocular inflammatory disorders. Adalimumab was effective in treating several autoimmune diseases, such as rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. In recent years, adalimumab has been used successfully in refractory cases of intraocular inflammation. Moreover, this biological agent showed good safety and efficacy profiles in ocular use including childhood uveitis. Switching from other anti-TNF-α agents to adalimumab may offer several advantages, such as easier administration, better patient compliance, and lower rate of adverse events. Adalimumab is a promising drug for the therapy of uveitis, although further studies are needed on its application in uveitis.

Keywords

AdalimumabUveitisImmunosuppressionMacular oedema

Copyright information

© Springer Science+Business Media B.V. 2011