International Ophthalmology

, Volume 31, Issue 2, pp 165–173

Adalimumab (Humira): a promising monoclonal anti-tumor necrosis factor alpha in ophthalmology

  • Piergiorgio Neri
  • Manuela Zucchi
  • Pia Allegri
  • Marta Lettieri
  • Cesare Mariotti
  • Alfonso Giovannini
Review

DOI: 10.1007/s10792-011-9430-3

Cite this article as:
Neri, P., Zucchi, M., Allegri, P. et al. Int Ophthalmol (2011) 31: 165. doi:10.1007/s10792-011-9430-3

Abstract

Tumor necrosis factor alpha (TNF-α) is a key soluble mediator involved in the inflammatory cascade of many disorders including uveitis. Among the anti-TNF-α agents, one of the most used in immune-mediated diseases, such as inflammatory arthropathies, is adalimumab (Humira, Abbott Pharmaceutical Inc.), a fully humanized antibody. The purpose of this review is to analyze the main pharmacological and clinical aspects of adalimumab and its efficacy both in systemic and ocular inflammatory disorders. Adalimumab was effective in treating several autoimmune diseases, such as rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. In recent years, adalimumab has been used successfully in refractory cases of intraocular inflammation. Moreover, this biological agent showed good safety and efficacy profiles in ocular use including childhood uveitis. Switching from other anti-TNF-α agents to adalimumab may offer several advantages, such as easier administration, better patient compliance, and lower rate of adverse events. Adalimumab is a promising drug for the therapy of uveitis, although further studies are needed on its application in uveitis.

Keywords

AdalimumabUveitisImmunosuppressionMacular oedema

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Piergiorgio Neri
    • 1
    • 2
    • 5
  • Manuela Zucchi
    • 3
  • Pia Allegri
    • 4
  • Marta Lettieri
    • 1
    • 2
  • Cesare Mariotti
    • 1
    • 2
  • Alfonso Giovannini
    • 1
    • 2
  1. 1.The Eye ClinicAzienda Ospedaliera Universitaria-Ospedali Riuniti di AnconaAnconaItaly
  2. 2.Ophthalmology Section, The Neuroscience DepartmentPolytechnic University of MarcheAnconaItaly
  3. 3.The Dermatology ClinicAzienda Ospedaliera Universitaria-Ospedali Riuniti di AnconaAnconaItaly
  4. 4.Uveitis Center, Ophthalmology DepartmentLavagna HospitalGenoaItaly
  5. 5.Clinica OculisticaAzienda Ospedaliera Universitaria-Ospedali Riuniti di AnconaTorrette-AnconaItaly