International Ophthalmology

, Volume 27, Issue 1, pp 59–61

Retinal pigment epithelial tear after intravitreal ranibizumab for subfoveal CNV secondary to AMD

Case Report

DOI: 10.1007/s10792-007-9066-5

Cite this article as:
Apte, R.S. Int Ophthalmol (2007) 27: 59. doi:10.1007/s10792-007-9066-5



To report a case of retinal pigment epithelial tear following intravitreal ranibizumab injection for subfoveal choroidal neovascularization.


Retrospective single case review.


A 78-year-old Caucasian female was treated with intravitreal ranibizumab for occult subfoveal choroidal neovascularization (CNV) from age-related macular degeneration (AMD). She returned for evaluation with decreased vision and was found to have a retinal pigment epithelial tear on biomicroscopy. Fluorescein angiography and OCT testing confirmed the clinical findings.


Although a pigment epithelial tear in neovascular AMD can represent natural history, prior reports of such tears after thermal laser, photodynamic therapy with verteporfin and following intravitreal injection of pegaptanib Na combined with this case report suggest that clinicians should be aware of and monitor patients for the possibility of this complication after intravitreal injections of ranibizumab.


RanibizumabAMDRPE tearIntravitreal injections

Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  1. 1.Department of Ophthalmology and Visual SciencesWashington University School of MedicineSt. LouisUSA
  2. 2.Barnes Retina InstituteWashington University School of MedicineSt. LouisUSA