Inflammation in acute and chronic neurological and psychiatric diseases

Inflammopharmacology

, Volume 20, Issue 3, pp 103-107

First online:

Inflammation in neurological and psychiatric diseases

  • Parto S. KhansariAffiliated withCalifornia Northstate University College of Pharmacy Email author 
  • , Beata SperlaghAffiliated withLaboratory of Molecular Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences (IEM HAS)

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Abstract

In recent years, compelling evidence suggests that inflammation plays a critical role in the pathology of a vast number of neurological diseases such as stroke, Parkinson’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis as well as neuropsychiatric diseases such as major depression and schizophrenia. Despite emerging evidence in human and animal models alike, modulating inflammatory responses have yet to be proven as an effective treatment to prevent or delay the progression of these diseases. The primary focus of this special edition is to highlight some of our current findings on the complexities of targeting neuroinflammation as a novel therapy, and its role in neurological and psychiatric disorders.

Keywords

Neuroinflammation Psychiatric diseases Stroke Alzheimer’s disease Parkinson’s disease Major depression Schizophrenia Acute neurological diseases Chronic neurological diseases Astrocytes Microglia Pro-inflammatory cytokines NSAIDs