Short Communication

Inflammopharmacology

, Volume 19, Issue 4, pp 235-241

First online:

Modulation of lipopolysaccharide-induced pro-inflammatory mediators by an extract of Glycyrrhiza glabra and its phytoconstituents

  • P. ThiyagarajanAffiliated withDepartment of Cellular Assay, R&D Centre, Natural Remedies Pvt. Ltd
  • , C. V. ChandrasekaranAffiliated withDepartment of Cellular Assay, R&D Centre, Natural Remedies Pvt. Ltd Email author 
  • , H. B. DeepakAffiliated withDepartment of Cellular Assay, R&D Centre, Natural Remedies Pvt. Ltd
  • , Amit AgarwalAffiliated withDepartment of Cellular Assay, R&D Centre, Natural Remedies Pvt. Ltd

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Abstract

Objective

To evaluate the inhibitory property of de-glycyrrhizinated extract of Glycyrrhiza glabra root and its phytoconstituents (glabridin, isoliquiritigenin and glycyrrhizin) on LPS-induced production of pro-inflammatory mediators.

Materials and methods

Inhibitory effect of G. glabra extract and its phytoconstituents were studied on lipopolysaccharide (LPS)-induced nitric oxide (NO), interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) levels in J774A.1 murine macrophages.

Results

G. glabra and isoliquiritigenin significantly inhibited LPS stimulated NO, IL-1 beta and IL-6 production. Glabridin showed significant inhibition of NO and IL-1 beta release, but failed to attenuate IL-6 levels at the tested concentrations. In addition, glycyrrhizin did not exhibit inhibitory response towards any of the LPS-induced pro-inflammatory mediators at the tested concentrations.

Conclusion

From the results we speculate that the inhibitory effect of G. glabra extract on LPS-induced pro-inflammatory mediators is influenced by glabridin and isoliquiritigenin and is not contributed by glycyrrhizin.

Keywords

Glycyrrhiza glabra Phytoconstituents (glabridin, isoliquiritigenin and glycyrrhizin) Inflammation Pro-inflammatory mediators (NO, IL-1 beta and IL-6)