Inflammopharmacology

, Volume 16, Issue 1, pp 48–52

Anti-inflammatory effect of α, β-Amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitis

  • S. A. Holanda Pinto
  • L. M. S. Pinto
  • G. M. A. Cunha
  • M. H. Chaves
  • F. A. Santos
  • V. S. Rao
Short Communication

DOI: 10.1007/s10787-007-1609-x

Cite this article as:
Holanda Pinto, S.A., Pinto, L.M.S., Cunha, G.M.A. et al. Inflammopharmacol (2008) 16: 48. doi:10.1007/s10787-007-1609-x
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Abstract.

This study was aimed to evaluate the anti-inflammatory potential of triterpene α, β-amyrin in rats on acute phase periodontitis. Periodontitis was induced by ligature placement around the maxillary right second molar tooth. Rats (n = 8/group) were pretreated with α, β-amyrin (5 and 10 mg/kg, p. o.), two hours before the induction of periodontal inflammation. Sham-operated and positive controls (lumiracoxib and dexamethasone) were included. Six hours later, plasma levels of TNF-alpha were analysed. Rats were sacrificed at 24 h, and the gingival tissue analysed for myeloperoxidase (MPO) and thiobarbituric acid-reactive substances (TBARS), as measures of neutrophil influx and lipid-peroxidation, respectively α, β-Amyrin as well as dexamethasone significantly inhibited the periodontitis-associated increases of TNF-alpha, and the gingival MPO and TBARS. α, β-Amyrin effect was more prominent at 5 mg/kg. Lumiracoxib manifested varied influence on the studied parameters. These results provide evidence to show that α, β-Amyrin retards acute inflammation in rat model of periodontitis and warrant further study on its efficacy to prevent chronic periodontitis-associated bone loss.

Keywords:

α, β-Amyrin triterpene acute phase periodontitis TNF-alpha MPO and TBARS anti-inflammatory activity 

Copyright information

© Springer 2008

Authors and Affiliations

  • S. A. Holanda Pinto
    • 1
  • L. M. S. Pinto
    • 1
  • G. M. A. Cunha
    • 1
  • M. H. Chaves
    • 2
  • F. A. Santos
    • 1
  • V. S. Rao
    • 1
  1. 1.Department of Physiology and Pharmacology, Post-Graduation Programme in Medical Sciences, Faculty of MedicineFederal University of CearaFortalezaBrazil
  2. 2.Department of Organic and Inorganic ChemistryFederal University of Piaui, PiTeresinaBrazil

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