Inflammation

, Volume 37, Issue 4, pp 1091–1101

Protective Effect of Carvacrol on Acute Lung Injury Induced by Lipopolysaccharide in Mice

Article

DOI: 10.1007/s10753-014-9833-1

Cite this article as:
Feng, X. & Jia, A. Inflammation (2014) 37: 1091. doi:10.1007/s10753-014-9833-1

Abstract

Carvacrol, the major component of Plectranthus amboinicus, has been known to exhibit anti-inflammatory activities. The aim of this study was to investigate the effects of carvacrol on lipopolysaccharide (LPS)-induced endotoxemia and acute lung injury (ALI) in mice. Mice were injected intraperitoneally (i.p.) with LPS and the mortality of mice for 7 days were observed twice a day. Meanwhile, the protective effect of carvacrol (20, 40 or 80 mg/kg) on LPS-induced endotoxemia were detected. Using an experimental model of LPS-induced ALI, we examined the effect of carvacrol in resolving lung injury. The results showed that carvacrol could improve survival during lethal endotoxemia and attenuate LPS-induced ALI in mice. The anti-inflammatory mechanisms of carvacrol may be due to its ability to inhibit NF-κB and MAPKs signaling pathways, thereby inhibiting inflammatory cytokines TNF-α, IL-6 and IL-1β production.

KEY WORDS

carvacrolacute lung injuryLPSNF-κBMAPK

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Guangdong Haid Institute of Animal Husbandry and VeterinaryGuangzhouChina