Inflammation

, Volume 36, Issue 6, pp 1453–1459

Valproic Acid Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice

  • Mu-huo Ji
  • Guo-min Li
  • Min Jia
  • Si-hai Zhu
  • Da-peng Gao
  • Yun-xia Fan
  • Jing Wu
  • Jian-jun Yang
Article

DOI: 10.1007/s10753-013-9686-z

Cite this article as:
Ji, M., Li, G., Jia, M. et al. Inflammation (2013) 36: 1453. doi:10.1007/s10753-013-9686-z

Abstract

Valproic acid (VPA) has been shown to exert anti-inflammatory and antioxidant effects in a range of diseases including septic shock. However, the effects of VPA on lipopolysaccharide (LPS)-induced acute lung injury (ALI) remains not well understood. We found that VPA pretreatment attenuated the LPS-induced ALI, as evidenced by the reduced histological scores, myeloperoxidase activity, and wet-to-dry weight ratio in the lung tissues. This was accompanied by the downregulated nuclear factor kappa B (NF-κB) p65, nitric oxide, and inducible nitric oxide synthase in the lung tissues and the decreased levels of tumor necrosis factor alpha and interleukin-1β in the bronchoalveolar lavage fluid. Furthermore, VPA reduced the nuclear histone deacetylase (HDAC)3 expression whereas increased the cytoplasmic HDAC3 expression. Our results suggested that VPA attenuates the LPS-induced ALI via inhibiting the NF-κB activation probably through a mechanism depending on HDAC3 redistribution.

KEY WORDS

sepsispro-inflammatory cytokineHDACsacute lung injury

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Mu-huo Ji
    • 1
  • Guo-min Li
    • 2
  • Min Jia
    • 1
  • Si-hai Zhu
    • 1
  • Da-peng Gao
    • 1
  • Yun-xia Fan
    • 2
  • Jing Wu
    • 1
  • Jian-jun Yang
    • 1
  1. 1.Department of Anesthesiology, Jinling Hospital, School of MedicineNanjing UniversityNanjingChina
  2. 2.Department of Anesthesiology and Intensive Care, Jintan HospitalJiangsu UniversityChangzhouChina