Inflammation

, Volume 36, Issue 3, pp 680–688

Propofol Attenuates Pulmonary Injury Induced by Collapse and Reventilation of Lung in Rabbits

  • Hong-Beom Bae
  • Mei Li
  • Seong-Heon Lee
  • Cheol-Won Jeong
  • Seok-Jai Kim
  • Heong-Seok Kim
  • Sung-Su Chung
  • Sang-Hyun Kwak
Article

DOI: 10.1007/s10753-012-9592-9

Cite this article as:
Bae, H., Li, M., Lee, S. et al. Inflammation (2013) 36: 680. doi:10.1007/s10753-012-9592-9

Abstract

Propofol is an anesthetic drug with antioxidant and anti-inflammatory properties. We previously found that propofol attenuated lipopolysaccharide-induced acute lung injury in rabbits. This study was performed to evaluate the effects of propofol on lung injury caused by collapse and reventilation in rabbits. The wet/dry weight ratio of the lung, lung injury scores, percentage of polymorphonuclear leukocytes, albumin concentration, malondialdehyde, and interleukin-8 levels in bronchoalveolar lavage fluid were significantly increased in both lungs of the reventilation group. The degree of increase in these parameters was more significant in the right (reventilated) than in the left (non-reventilated) lung. Propofol attenuated these changes. These findings suggest that reventilation of a collapsed lung can cause injury in the contralateral non-reventilated lung as well as the reventilated lung. Propofol may provide a beneficial effect on lung injury induced by collapse and reventilation of the lung.

KEY WORDS

reventilationlung injurypropofolischemia–reperfusioninflammation

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Hong-Beom Bae
    • 1
  • Mei Li
    • 2
  • Seong-Heon Lee
    • 1
  • Cheol-Won Jeong
    • 3
  • Seok-Jai Kim
    • 1
  • Heong-Seok Kim
    • 1
  • Sung-Su Chung
    • 3
  • Sang-Hyun Kwak
    • 1
  1. 1.Department of Anesthesiology and Pain MedicineChonnam National University, Medical SchoolGwangjuSouth Korea
  2. 2.Department of AnesthesiologyThe First Affiliated Hospital, Zhejiang University School of MedicineHangzhouChina
  3. 3.Department of AnesthesiologyChonnam National University School of DentistryGwangjuSouth Korea