Article

Inflammation

, Volume 36, Issue 1, pp 35-41

First online:

Is the IL-10 Promoter Polymorphism at Position -592 Associated with Immune System-Related Diseases?

  • Mojgan Noroozi KarimabadAffiliated withMolecular Medicine Research Center, Rafsanjan University of Medical Sciences
  • , Mohammad Kazemi ArababadiAffiliated withDepartment of Microbiology, Hematology and Immunology, Faculty of Medicine and Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical SciencesImmunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences Email author 
  • , Elham HakimizadehAffiliated withPhysiology and Pharmacology Research Center, Rafsanjan University of Medical Sciences
  • , Hassan Yousefi DaredoriAffiliated withDepartment of Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences
  • , Mahmood NazariAffiliated withDepartment of Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences
  • , Gholamhossein HassanshahiAffiliated withMolecular Medicine Research Center, Rafsanjan University of Medical Sciences
  • , Derek KennedyAffiliated withSchool of Biomolecular and Physical Science, Eskitis Institute for Cell and Molecular Therapies, Griffith University Nathan

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Abstract

Immune responses are the main causes of immune system-related diseases such as hypersensitivities and autoimmunity. It has also been established that cytokines play key roles in the regulation of immune responses which have been shown to be important in the pathogenesis of the diseases. IL-10, the main anti-inflammatory cytokine, is produced by several immune cells such as T regulatory and Th2 lymphocytes, activated macrophages, B regulatory lymphocytes as well as other cell types. It plays a key role in the regulation of immune responses after microbe elimination (homeostasis) and against self-antigens to prevent hypersensitivity and autoimmune diseases, respectively. Studies showed that a single nucleotide polymorphism (SNP) at the -592 position of IL-10 is associated with its regulation of expression. This review addresses the recent information regarding the association of the polymorphism at position -592 of IL-10 with immune-related diseases including type 2 diabetes with and without nephropathy, multiple sclerosis, and asthma with an emphasize on Iranian patients.

KEY WORDS

IL-10 polymorphism diabetes nephropathy multiple sclerosis asthma