Inflammation

, Volume 35, Issue 2, pp 713–722

Protective Effects of Radon Inhalation on Carrageenan-Induced Inflammatory Paw Edema in Mice

  • Takahiro Kataoka
  • Junichi Teraoka
  • Akihiro Sakoda
  • Yuichi Nishiyama
  • Keiko Yamato
  • Mayuko Monden
  • Yuu Ishimori
  • Takaharu Nomura
  • Takehito Taguchi
  • Kiyonori Yamaoka
Article

DOI: 10.1007/s10753-011-9364-y

Cite this article as:
Kataoka, T., Teraoka, J., Sakoda, A. et al. Inflammation (2012) 35: 713. doi:10.1007/s10753-011-9364-y

Abstract

We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice. Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2,000 Bq/m3 of radon for 24 h. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activities and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activates antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-α) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-α levels were lower in the radon-treated mice than in sham-treated mice. In addition, SOD and catalase activities in paws were significantly higher in the radon-treated mice than in the sham-treated mice. These findings indicated that radon inhalation had anti-inflammatory effects and inhibited carrageenan-induced inflammatory paw edema.

KEY WORDS

radon inhalationinflammationcarrageenanedemaantioxidative function

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Takahiro Kataoka
    • 1
  • Junichi Teraoka
    • 1
  • Akihiro Sakoda
    • 2
  • Yuichi Nishiyama
    • 1
  • Keiko Yamato
    • 1
  • Mayuko Monden
    • 3
  • Yuu Ishimori
    • 2
  • Takaharu Nomura
    • 4
  • Takehito Taguchi
    • 1
  • Kiyonori Yamaoka
    • 1
  1. 1.Graduate School of Health SciencesOkayama UniversityOkayama-shiJapan
  2. 2.Ningyo-toge Environmental Engineering CenterJapan Atomic Energy AgencyTomata-gunJapan
  3. 3.Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical SciencesFukuyama UniversityFukuyama-shiJapan
  4. 4.Radiation Safety Research CenterCentral Research Institute of Electric Power IndustryKomae-shiJapan