Inflammation

, Volume 35, Issue 1, pp 98–113

Chemical Mediators of Inflammation and Resolution in Post-Operative Abdominal Aortic Aneurysm Patients

  • Padmini S. Pillai
  • Stanley Leeson
  • Timothy F. Porter
  • Christopher D. Owens
  • Ji Min Kim
  • Michael S. Conte
  • Charles N. Serhan
  • Simon Gelman
Article

DOI: 10.1007/s10753-011-9294-8

Cite this article as:
Pillai, P.S., Leeson, S., Porter, T.F. et al. Inflammation (2012) 35: 98. doi:10.1007/s10753-011-9294-8

Abstract

Temporal–metabolomic studies of local mediators during inflammation and its resolution uncovered novel pathways and mediators, e.g., lipoxins, resolvins, and protectins that stimulate key resolution responses. Since these studies were carried out with isolated human cells and in animal models, it is important to determine in humans whether temporal profiles between pro-inflammatory mediators and pro-resolving mediators are demonstrable in vivo. To this end, we examined patients undergoing abdominal aortic aneurysm (AAA) surgery. Profiles of mediators including eicosanoids were assessed in addition to pro-resolving mediators. The results demonstrate temporal relationships for local-acting peptides (e.g., VEGF, IL-10, TGFβ) and lipid mediators (leukotrienes and resolvins). In addition, profiles obtained for AAA patients divided into two groups based on their temporal profile: one group consistent with a pro-inflammatory and another with a resolving profile. Together, these translational metabolomic profiles demonstrate for the first time the temporal relationships between local mediators in humans relevant in inflammation resolution.

KEY WORDS

metabolomics resolution DHA EPA leukotrienes resolvins 

Abbreviations

17-HDHA

17S-hydroxy-docosa-4Z,7Z,10Z,13Z,15E,19Z-hexaenoic acid

18-HEPE

18-hydroxy-eicosapentaenoic acid

12-HETE

12-hydroxyeicosatetraenoic acid

15-HETE

15-hydroxyeicosatetraenoic acid

LOX

lipoxygenase

LTB4

leukotriene B4 5S,12R-dihydroxy-eicosa-6Z,8E,10E,14Z-tetraenoic acid

LXA4

lipoxin A45S,6R,15S-trihydroxy-eicosa-7E,9E,11Z,13E-tetraenoic acid

15-epi-LXA4

5S,6R,15R-trihydroxy-eicosa-7E,9E,11Z,13E-tetraenoic acid

PGE2

prostaglandin E2, 9-oxo-11a,15S-dihydroxy-prosta-5Z,13E-dien-1-oic acid

Rv

resolvin

RvE1

resolvin E1 (5S,12R,18R-trihydroxy-eicosa-6Z,8E,10E,14Z,16E-pentaenoic acid)

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Padmini S. Pillai
    • 1
  • Stanley Leeson
    • 2
  • Timothy F. Porter
    • 1
  • Christopher D. Owens
    • 3
  • Ji Min Kim
    • 3
  • Michael S. Conte
    • 3
  • Charles N. Serhan
    • 1
    • 4
  • Simon Gelman
    • 1
    • 2
  1. 1.Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Department of Anesthesiology, Perioperative and Pain MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  3. 3.Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  4. 4.Director, Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

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