Inflammation

, Volume 34, Issue 4, pp 291–301

Anti-inflammatory and Anti-oxidant Properties of Curcuma longa (Turmeric) Versus Zingiber officinale (Ginger) Rhizomes in Rat Adjuvant-Induced Arthritis

  • Gamal Ramadan
  • Mohammed Ali Al-Kahtani
  • Wael Mohamed El-Sayed
Article

DOI: 10.1007/s10753-010-9278-0

Cite this article as:
Ramadan, G., Al-Kahtani, M.A. & El-Sayed, W.M. Inflammation (2011) 34: 291. doi:10.1007/s10753-010-9278-0

Abstract

Turmeric (rich in curcuminoids) and ginger (rich in gingerols and shogaols) rhizomes have been widely used as dietary spices and to treat different diseases in Ayurveda/Chinese medicine since antiquity. Here, we compared the anti-inflammatory/anti-oxidant activity of these two plants in rat adjuvant-induced arthritis (AIA). Both plants (at dose 200 mg/kg body weight) significantly suppressed (but with different degrees) the incidence and severity of arthritis by increasing/decreasing the production of anti-inflammatory/pro-inflammatory cytokines, respectively, and activating the anti-oxidant defence system. The anti-arthritic activity of turmeric exceeded that of ginger and indomethacin (a non-steroidal anti-inflammatory drug), especially when the treatment started from the day of arthritis induction. The percentage of disease recovery was 4.6–8.3% and 10.2% more in turmeric compared with ginger and indomethacin (P < 0.05), respectively. The present study proves the anti-inflammatory/anti-oxidant activity of turmeric over ginger and indomethacin, which may have beneficial effects against rheumatoid arthritis onset/progression as shown in AIA rat model.

KEY WORDS

rat adjuvant-induced arthritisanti-inflammatory/anti-oxidant activityCurcuma longaindomethacinZingiber officinale

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Gamal Ramadan
    • 1
    • 2
  • Mohammed Ali Al-Kahtani
    • 1
  • Wael Mohamed El-Sayed
    • 1
    • 2
  1. 1.Biological Science Department, College of ScienceKing Faisal UniversityAl-HufofKingdom of Saudi Arabia
  2. 2.Zoology Department, Faculty of ScienceAin Shams UniversityCairoEgypt