, Volume 34, Issue 3, pp 184-192

First online:

A Role of Piperine on Monosodium Urate Crystal-Induced Inflammation—An Experimental Model of Gouty Arthritis

  • Evan Prince SabinaAffiliated withSchool of Bio Sciences and Technology, VIT University
  • , Shruthi NagarAffiliated withSchool of Bio Sciences and Technology, VIT University
  • , Mahaboobkhan RasoolAffiliated withSchool of Bio Sciences and Technology, VIT University Email author 

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In the present study, the anti-inflammatory effect of piperine was investigated on monosodium urate crystal-induced inflammation in mice, an experimental model for gouty arthritis, and compared it with that of the nonsteroidal anti-inflammatory drug, indomethacin. The levels of lysosomal enzymes, lipid peroxidation, tumor necrosis factor-α, and paw volume were increased significantly, and the activities of antioxidant status were in turn decreased in monosodium urate crystal-induced mice, whereas these changes were reverted to near normal levels upon piperine (30 mg/kg b.wt, i.p.) treatment. In vitro, piperine (50/100 ug/ml) suppressed the level of β-glucuronidase and lactate dehydrogenase in monosodium urate crystal-incubated polymorphonuclear leucocytes in concentration-dependent manner when compared to control cells. Thus, the present study clearly indicated that piperine inhibit the monosodium urate crystal-induced inflammation and can be regarded as therapeutic drug for the treatment of acute gouty arthritis.


piperine, gouty arthritis indomethacin lysosomal enzymes polymorphonuclear leucocytes tumor necrosis factor-α