Inflammation

, Volume 34, Issue 3, pp 161–170

Central Adiposity Rather Than Total Adiposity Measurements Are Specifically Involved in the Inflammatory Status from Healthy Young Adults

  • Helen Hermana M. Hermsdorff
  • M. Ángeles Zulet
  • Blanca Puchau
  • J. Alfredo Martínez
Article

DOI: 10.1007/s10753-010-9219-y

Cite this article as:
Hermsdorff, H.H.M., Zulet, M.Á., Puchau, B. et al. Inflammation (2011) 34: 161. doi:10.1007/s10753-010-9219-y

Abstract

This study assessed the potential association of some proinflammatory markers with adiposity (total vs. central) and metabolic features in young adults. Measurements included body composition, lifestyle features, blood biochemical, and selected inflammatory indicators on 154 healthy subjects (53 M/101 F; 21.5 ± 3 years; 22.1 ± 2.6 kg/m2). Those subjects with higher waist circumference (WC) and waist–hip ratio (WHR) showed higher (P < 0.05) C-reactive protein (CRP), complement C3, interleukin-6 (IL6), and retinol binding protein-4 (RBP4) concentrations, while only IL6 was positively associated with total body fat (%). Furthermore, CRP and RBP4 were higher in former/current smokers, as compared to never smokers (P < 0.05). Some indicators of glucose (homeostasis model assessment—insulin resistance) and lipid metabolism (total cholesterol/high density lipoprotein—cholesterol and triglycerides) were positively associated with the assayed inflammatory markers (P < 0.05). The findings of this cross-sectional study indicate that central adiposity-related indicators (WC/WHR) correlated better than those assessing total adiposity with plasma proinflammatory markers, which additionally were associated with lifestyle and metabolic features in healthy young adults.

KEY WORDS

adiposity waist circumference lifestyle inflammation humans 

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Helen Hermana M. Hermsdorff
    • 1
  • M. Ángeles Zulet
    • 1
  • Blanca Puchau
    • 1
  • J. Alfredo Martínez
    • 1
  1. 1.Department of Nutrition, Food Science, Physiology and ToxicologyUniversity of NavarraPamplonaSpain

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