Inflammation

, Volume 33, Issue 2, pp 82–91

The Effect of Epigallocatechin Gallate on Lipopolysaccharide-Induced Acute Lung Injury in a Murine Model

  • Hong-Beom Bae
  • Mei Li
  • Jong-Phil Kim
  • Seok-Jai Kim
  • Cheol-Won Jeong
  • Hyung-Gon Lee
  • Woong-Mo Kim
  • Hyung-Seok Kim
  • Sang-Hyun Kwak
Article

DOI: 10.1007/s10753-009-9161-z

Cite this article as:
Bae, HB., Li, M., Kim, JP. et al. Inflammation (2010) 33: 82. doi:10.1007/s10753-009-9161-z
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Abstract

This study was performed to evaluate the effects of epigallocatechin 3 gallate (EGCG) on lipopolysaccharide (LPS)-induced acute lung injury in a murine model. In the present study, production of TNF-α and MIP-2 and activation of extracellular signal-regulated kinases (ERK)1/2, c-Jun amino terminal kinases (JNK) and p38 in RAW264.7 cells were measured. EGCG inhibited the production of TNF-α and MIP-2, and attenuated phosphorylation levels of ERK1/2 and JNK, but not p38 in RAW264.7 cells stimulated with LPS. Also, EGCG attenuated the production of TNF-α and MIP-2, and the phosphorylation of ERK1/2 and JNK in the lungs of mice administered with LPS intratracheally. It reduced wet/dry weight ratio, histological severities, and neutrophil accumulation in the lungs in mice given LPS. Our results showed that EGCG attenuated LPS-induced lung injury by suppression of the MIP-2 and TNF-α production, and ERK1/2 and JNK activation in macrophage stimulated with LPS.

KEY WORDS

acute lung injury cytokine EGCG mitogen activated protein kinases 

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Hong-Beom Bae
    • 1
  • Mei Li
    • 1
    • 3
  • Jong-Phil Kim
    • 1
  • Seok-Jai Kim
    • 1
  • Cheol-Won Jeong
    • 1
  • Hyung-Gon Lee
    • 1
  • Woong-Mo Kim
    • 1
  • Hyung-Seok Kim
    • 2
  • Sang-Hyun Kwak
    • 1
  1. 1.Departments of Anesthesiology and Pain MedicineChonnam National University, Medical SchoolGwangjuSouth Korea
  2. 2.Department of Forensic MedicineChonnam National University, Medical SchoolGwangjuSouth Korea
  3. 3.Brain Korea 21 Project, Center for Biomedical Human Resources at Chonnam National UniversityGwangjuSouth Korea

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