Inflammation

, Volume 28, Issue 5, pp 263–270

Xanthii Fructus Inhibits Inflammatory Responses in LPS-Stimulated Mouse Peritoneal Macrophages

  • Hyo-Jin An
  • Hyun-Ja Jeong
  • Eun-Hee Lee
  • Yun-Kyung Kim
  • Woo-Jun Hwang
  • Su-Jin Yoo
  • Seung-Heon Hong
  • Hyung-Min Kim
Article

DOI: 10.1007/s10753-004-6049-9

Cite this article as:
An, HJ., Jeong, HJ., Lee, EH. et al. Inflammation (2004) 28: 263. doi:10.1007/s10753-004-6049-9

Abstract

Xanthii Fructus (XF) is an herb widely used in medicine for the treatment of a variety of inflammatory pathologies. In this study, using mouse peritoneal macrophages, we have examined whether XF affects nitric oxide (NO), tumor necrosis factor (TNF)-α, and interleukin (IL)-12p40 production induced by interferon (IFN)-γ and lipopolysaccharide (LPS). XF inhibits IFN-γ and LPS-induced NO production in a dose dependent manner. The decrease in NO synthesis was reflected as a decreased amount of inducible NO synthase protein. Furthermore, we also found that XF inhibits pro-inflammatory cytokine TNF-α production. However, treatment of XF in peritoneal macrophages had no effect on IL-12p40 production. These findings suggest that XF may be used in controlling macrophages-mediated inflammatory diseases.

Key Words

Xanthii Fructusperitoneal macrophagenitric oxidetumor necrosis factor-αinflammation

Copyright information

© Springer Science + Business Media, Inc. 2004

Authors and Affiliations

  • Hyo-Jin An
    • 1
    • 2
  • Hyun-Ja Jeong
    • 1
  • Eun-Hee Lee
    • 3
  • Yun-Kyung Kim
    • 2
  • Woo-Jun Hwang
    • 4
  • Su-Jin Yoo
    • 5
  • Seung-Heon Hong
    • 2
  • Hyung-Min Kim
    • 1
    • 6
  1. 1.College of Oriental MedicineKyung Hee UniversitySeoulRepublic of Korea
  2. 2.College of PharmacyWonkwang UniversityIksanRepublic of Korea
  3. 3.Division of Beauty ArtsJeonbuk Science CollegeJeonegeupRepublic of Korea
  4. 4.Professional Graduate School of Oriental MedicineWonkwang UniversityIksanRepublic of Korea
  5. 5.Department of EmergencyWonkwang University School of MedicineIksanRepublic of Korea
  6. 6.Department of PharmacologyCollege of Oriental Medicine, Kyung Hee UniversitySeoulRepublic of Korea