Biodegradation of magnetic nanoparticles evaluated from Mössbauer and magnetization measurements
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- Mischenko, I., Chuev, M., Cherepanov, V. et al. Hyperfine Interact (2013) 219: 57. doi:10.1007/s10751-012-0710-8
In order to extract a quantitative information about characteristics of the magnetic nanoparticles injected into a living organism it is necessary to define a model of the magnetic dynamics for fitting self-consistently the whole set of the experimental data, specifically, the evolution of Mössbauer spectral shape with temperature and external magnetic field as well as the magnetization curves. We have developed such a model and performed such an analysis of the temperature- and magnetic field-dependent spectra and magnetization curves of nanoparticles injected into mice. This allowed us to reliably evaluate changes in the characteristics of the residual particles and their chemical transformation to paramagnetic ferritin-like forms in different mouse organs as a function of time. Actually, the approach makes it possible to quantitatively characterize biodegradation and biotransformation of magnetic nanoparticles delivered in a body.