Clinical use of novel biomarkers in heart failure: towards personalized medicine
- Daniela SchmitterAffiliated withMomentum Research, Inc.
- , Gadi CotterAffiliated withMomentum Research, Inc.
- , Adriaan A. VoorsAffiliated withDepartment of Cardiology, University Medical Center Groningen, University of Groningen Email author
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Biomarkers play an important role in heart failure. They provide us information about the mechanisms involved in specific types of heart failure and can identify patients at higher risk. Although the majority of biomarker studies in heart failure focus on their prognostic value, the clinical applicability of prognostication in heart failure needs to be established. However, biomarkers can be used for many other purposes. For example, they can help us with the diagnosis of heart failure, and they can be used to select our therapy, leading to personalized tailored therapy. Finally, when biomarkers are causally involved in the disease process, they can even become targets for therapy. The present paper reviews the established and potential value of the novel heart failure biomarkers, mid-regional atrial natriuretic peptide, soluble ST2, growth differentiation factor 15, galectin-3, renal tubular damage markers, and microRNAs. Their potential clinical value will be discussed and compared with the reference markers, the natriuretic peptides.
KeywordsHeart failure Biomarkers Personalized medicine Soluble ST2 Galectin-3 MicroRNAs
- Clinical use of novel biomarkers in heart failure: towards personalized medicine
Heart Failure Reviews
Volume 19, Issue 3 , pp 369-381
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Heart failure
- Personalized medicine
- Soluble ST2
- Industry Sectors
- Author Affiliations
- 1. Momentum Research, Inc., Hagmattstrasse 17, 4123, Allschwil, Switzerland
- 2. Momentum Research, Inc., 3100 Tower Boulevard, Durham, NC, 27707, USA
- 3. Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands