Heart Failure Reviews

, Volume 19, Issue 2, pp 259–266

Physiologic and hematologic concerns of rotary blood pumps: what needs to be improved?

  • Tohid Pirbodaghi
  • Siavash Asgari
  • Chris Cotter
  • Kevin Bourque
Article

DOI: 10.1007/s10741-013-9389-4

Cite this article as:
Pirbodaghi, T., Asgari, S., Cotter, C. et al. Heart Fail Rev (2014) 19: 259. doi:10.1007/s10741-013-9389-4

Abstract

Over the past few decades, advances in ventricular assist device (VAD) technology have provided a promising therapeutic strategy to treat heart failure patients. Despite the improved performance and encouraging clinical outcomes of the new generation of VADs based on rotary blood pumps (RBPs), their physiologic and hematologic effects are controversial. Currently, clinically available RBPs run at constant speed, which results in limited control over cardiac workload and introduces blood flow with reduced pulsatility into the circulation. In this review, we first provide an update on the new challenges of mechanical circulatory support using rotary pumps including blood trauma, increased non-surgical bleeding rate, limited cardiac unloading, vascular malformations, end-organ function, and aortic valve insufficiency. Since the non-physiologic flow characteristic of these devices is one of the main subjects of scientific debate in the literature, we next emphasize the latest research regarding the development of a pulsatile RBP. Finally, we offer an outlook for future research in the field.

Keywords

Ventricular assist devicesRotary blood pumpsHeart failureContinuous flowPulsatile flow

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Tohid Pirbodaghi
    • 1
    • 2
    • 4
  • Siavash Asgari
    • 3
  • Chris Cotter
    • 4
  • Kevin Bourque
    • 4
  1. 1.Graduate School for Cellular and Biomedical SciencesUniversity of BernBernSwitzerland
  2. 2.ARTORG Cardiovascular EngineeringUniversity of BernBernSwitzerland
  3. 3.Department of Surgery-Cardiac Section, School of MedicineYale UniversityNew HavenUSA
  4. 4.Thoratec CorporationBurlingtonUSA