Heart Failure Reviews

, Volume 17, Issue 4, pp 683–691

Role of ACE2 in diastolic and systolic heart failure

  • Wang Wang
  • Sreedhar Bodiga
  • Subhash K. Das
  • Jennifer Lo
  • Vaibhav Patel
  • Gavin Y. Oudit
Article

DOI: 10.1007/s10741-011-9259-x

Cite this article as:
Wang, W., Bodiga, S., Das, S.K. et al. Heart Fail Rev (2012) 17: 683. doi:10.1007/s10741-011-9259-x

Abstract

A novel angiotensin-converting enzyme (ACE) homolog, named ACE2, is a monocarboxypeptidase which metabolizes several peptides. ACE2 degrades Angiotensin (Ang) II, a peptide with vasoconstrictive/proliferative effects, to generate Ang-(1-7), which acting through its receptor Mas exerts vasodilatory/anti-proliferative actions. In addition, as ACE2 is a multifunctional enzyme and its actions on other vasoactive peptides can also contribute to its vasoactive effects including the apelin-13 and apelin-17 peptides. The discovery of ACE2 corroborates the establishment of two counter-regulatory arms within the renin-angiotensin system. The first one is formed by the classical pathway involving the ACE-Ang II-AT1 receptor axis and the second arm is constituted by the ACE2-Ang 1-7/Mas receptor axis. Loss of ACE2 enhances the adverse pathological remodeling susceptibility to pressure-overload and myocardial infarction. ACE2 is also a negative regulator of Ang II-induced myocardial hypertrophy, fibrosis, and diastolic dysfunction. The ACE2-Ang 1-7/Mas axis may represent new possibilities for developing novel therapeutic strategies for the treatment of hypertension and cardiovascular diseases. In this review, we will summarize the biochemical and pathophysiological aspects of ACE2 with a focus on its role in diastolic and systolic heart failure.

Keywords

Angiotensin-converting enzyme 2Angiotensin IIAngiotensin 1-7Diastolic dysfunctionHypertensionHeart failure

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Wang Wang
    • 1
    • 2
  • Sreedhar Bodiga
    • 2
    • 3
  • Subhash K. Das
    • 2
    • 3
  • Jennifer Lo
    • 2
    • 3
  • Vaibhav Patel
    • 2
    • 3
  • Gavin Y. Oudit
    • 1
    • 2
    • 3
  1. 1.Department of PhysiologyUniversity of AlbertaEdmontonCanada
  2. 2.Division of Cardiology, Department of Medicine, Mazankowski Alberta Heart InstituteUniversity of AlbertaEdmontonCanada
  3. 3.Mazankowski Alberta Heart InstituteUniversity of AlbertaEdmontonCanada