Heart Failure Reviews

, Volume 16, Issue 3, pp 227–233

The molecular fingerprint of cardiac dyssynchrony and cardiac resynchronization therapy


    • Cardiovascular Center, Onze Lieve Vrouwziekenhuis
  • Chris Vrints
    • Cardiovascular Center, Onze Lieve Vrouwziekenhuis
    • Department of CardiologyUniversity of Antwerp
  • Jozef Bartunek
    • Cardiovascular Center, Onze Lieve Vrouwziekenhuis

DOI: 10.1007/s10741-010-9199-x

Cite this article as:
Vanderheyden, M., Vrints, C. & Bartunek, J. Heart Fail Rev (2011) 16: 227. doi:10.1007/s10741-010-9199-x


To date, cardiac resynchronization therapy remains the only treatment that enhances systolic function while improving long-term outcome and survival. Here, we review the molecular alterations associated with dyssynchronous heart failure and their reversibility induced by cardiac resynchronization therapy. We focus upon the molecular portrait of dyssynchronous heart failure and how cardiac resynchronization therapy influences electrophysiologic, metabolic and adrenergic pathways.


Dyssynchronous heart failureMolecular portraitGene expressionCardiac resynchronization therapy

Copyright information

© Springer Science+Business Media, LLC 2010