Heart Failure Reviews

, Volume 14, Issue 3, pp 143–153

Obstructive sleep apnea: the new cardiovascular disease. Part I: obstructive sleep apnea and the pathogenesis of vascular disease

Authors

  • Rami Khayat
    • The Ohio State University Sleep Heart ProgramThe Ohio State University
    • Division of Pulmonary, Critical Care, and Sleep MedicineThe Ohio State University
    • The Ohio State University Sleep Heart ProgramThe Ohio State University
  • Don HayesJr.
    • Departments of Pediatrics and Internal MedicineUniversity of Kentucky College of Medicine
Article

DOI: 10.1007/s10741-008-9112-z

Cite this article as:
Khayat, R., Patt, B. & Hayes, D. Heart Fail Rev (2009) 14: 143. doi:10.1007/s10741-008-9112-z

Abstract

Obstructive sleep apnea (OSA) is increasingly recognized as a novel cardiovascular risk factor. OSA is implicated in the pathogenesis of hypertension, left ventricular dysfunction, coronary artery disease and stroke. OSA exerts its negative cardiovascular consequences through its unique pattern of intermittent hypoxia. Endothelial dysfunction, oxidative stress, and inflammation are all consequences of OSA directly linked to intermittent hypoxia and critical pathways in the pathogenesis of cardiovascular disease in patients with OSA. This review will discuss the known mechanisms of vascular dysfunction in patients with OSA and their implications for cardiovascular disease.

Keywords

Obstructive sleep apnea Heart failure Endothelial dysfunction Intermittent hypoxia Oxidative stress

Copyright information

© Springer Science+Business Media, LLC 2008