Heart Failure Reviews

, Volume 13, Issue 4, pp 439–452

Pleiotropic effects of cardiac drugs on healing post-MI. The good, bad, and ugly

Article

DOI: 10.1007/s10741-008-9090-1

Cite this article as:
Jugdutt, B.I. Heart Fail Rev (2008) 13: 439. doi:10.1007/s10741-008-9090-1

Abstract

Healing after myocardial infarction (MI) is a well-orchestrated time-dependent process that involves inflammation, tissue repair with extracellular collagen matrix (ECCM) deposition and scar formation, and remodeling of myocardial structure, matrix, vasculature, and function. Rapid early ECCM degradation followed by slow ECCM replacement and maturation during post-MI healing results in a prolonged window of enhanced vulnerability to adverse remodeling. Decreased ECCM results in adverse ventricular remodeling, dysfunction, and rupture. Inflammation, a critical factor in normal healing, if impaired results in adverse remodeling and rupture. Several therapeutic drugs prescribed after MI exert pleiotropic effects that suppress ECCM and inflammation during healing and may have good, bad, or ugly consequences. This article reviews the potential impact of pleiotropic effects of some prototypic cardiac drugs such as renin-angiotensin-aldosterone system (RAAS) inhibitors, statins, and thrombolytics during healing post-ST-segment-elevation MI (STEMI), with special focus on inflammation, ECCM and remodeling, and implications in the elderly.

Keywords

STEMIHealingInflammationExtracellular collagen matrixPrototypic drugsRemodelingAging

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Division of Cardiology, Department of Medicine and Cardiovascular Research Group, Faculty of MedicineUniversity of AlbertaEdmontonCanada
  2. 2.Division of Cardiology, 2C2 Walter MacKenzie Health Sciences CentreUniversity of AlbertaEdmontonCanada