Original Paper

Journal of Molecular Histology

, Volume 44, Issue 2, pp 135-145

Upregulation of CBLL1 in rat brain cortex after lipopolysaccharide treated

  • Maohong CaoAffiliated withDepartment of Neurology, Affiliated Hospital of Nantong University
  • , Heyi ZhengAffiliated withDepartment of Neurology, Affiliated Hospital of Nantong University
  • , Xiang TanAffiliated withDepartment of Neurology, Affiliated Hospital of Nantong University
  • , Wei XuAffiliated withDepartment of Neurology, Affiliated Hospital of Nantong University
  • , Ying RuiAffiliated withDepartment of Neurology, Affiliated Hospital of Nantong University
  • , Lei LiAffiliated withDepartment of Neurology, Affiliated Hospital of Nantong University
  • , Xiaofei LiuAffiliated withDepartment of Neurology, Affiliated Hospital of Nantong University
  • , Guangfei XuAffiliated withDepartment of Neurology, Affiliated Hospital of Nantong University
  • , Gang CuiAffiliated withDepartment of Neurology, Affiliated Hospital of Nantong University
    • , Jian XuAffiliated withDepartment of Neurology, Affiliated Hospital of Nantong University
    • , Jianhua CaoAffiliated withDepartment of Neurology, Affiliated Hospital of Nantong University
    • , Kaifu KeAffiliated withDepartment of Neurology, Affiliated Hospital of Nantong University Email author 
    • , Qiyun WuAffiliated withDepartment of Neurology, Affiliated Hospital of Nantong University Email author 

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Abstract

CBLL1 (Casitas B-lineage lymphoma-transforming sequence-like protein 1) also known as Hakai, was originally identified as an E3 ubiquitin-ligase for the E-cadherin complex. Recent data have provided evidences for novel biological functional role of CBLL1 during tumor progression and other diseases. However, its distribution and function in the central nervous system (CNS) remains unclear. In this study, we found CBLL1 was significant up-regulation in cerebral cortex after LPS administration and immunofluorescent labeling indicated that CBLL1 was localized striking in the neurons. We also investigated co-staining of CBLL1 and active-caspase-3 and cyclin D1 in the cerebral cortex following LPS administration. Based on our data, we speculated that CBLL1 might play an important role in neuronal apoptosis following LPS administration and might provide a basis for the further study on its role in cell cycle re-entry in neuroinflammation in CNS.

Keywords

CBLL1 Lipopolysaccharide Apoptosis Rat