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RETRACTED ARTICLE: Effect of preischemic treatment with fenofibrate, a peroxisome proliferator-activated receptor-α ligand, on hepatic ischemia–reperfusion injury in rats

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This article was retracted on 12 May 2013

Abstract

Liver ischemia/reperfusion (I/R) injury is a serious clinical problem. The reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-α) are important mediators in liver I/R injury. This study was designed to investigate the effect of preischemic treatment with fenofibrate (Peroxisome proliferator-activated receptor- α agonist) on the oxidative stress and inflammatory response to hepatic I/R injury in rats. Hepatic I/R was induced by clamping the blood supply of the left lateral and median lobes of the liver for 60 min, followed by reperfusion for 4 h. Each animal group was pretreated with a single dose of fenofibrate (50 mg/kg body weight) intraperitoneally 1 h before ischemia. At the end of reperfusion, blood samples and liver tissues were obtained to assess serum alanine aminotransferase (ALT), TNF-α, hepatic malondialdehyde (MDA) and superoxide dismutase activity (SOD). Liver specimens were obtained and processed for light and electron microscopic study. Hepatic I/R induced a significant elevation of serum ALT and TNF-α with significant elevation of hepatic MDA and reduction of SOD activity. Histopathological examination revealed hepatic inflammation, necrosis and apoptosis. Preischemic treatment with fenofibrate at a dose of 50 mg/kg significantly attenuated the biochemical and structural alterations of I/R-induced liver injury.

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Correspondence to Vivian Boshra.

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A retraction note to this article is available at http://dx.doi.org/10.1007/s10735-013-9509-4.

The article has been retracted due to duplicate publication. It was first published by the same authors as "Effect of fenofibrate on the experimentally induced hepatic schema/reperfusion injury in rats: biochemical, light, and electronic microscopic studies" in the Egyptian Journal of Histology, volume 34 (pages 103-116).

An erratum to this article is available at http://dx.doi.org/10.1007/s10735-013-9509-4.

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Boshra, V., Moustafa, A.M. RETRACTED ARTICLE: Effect of preischemic treatment with fenofibrate, a peroxisome proliferator-activated receptor-α ligand, on hepatic ischemia–reperfusion injury in rats. J Mol Hist 42, 113–122 (2011). https://doi.org/10.1007/s10735-011-9313-y

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  • DOI: https://doi.org/10.1007/s10735-011-9313-y

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