Journal of Molecular Histology

, 40:269

Altered expression of cytokeratins in primary, recurrent and syndrome keratocystic odontogenic tumors

Authors

    • Department of Oral Pathology, Laboratory of Oral Surgical Pathology, School of DentistryFederal University of Bahia
    • Faculdade de Odontologia-UFBA
  • Gabriel Queiroz Vasconcelos Oliveira
    • Department of Oral Pathology, Laboratory of Oral Surgical Pathology, School of DentistryFederal University of Bahia
  • Clarissa Araújo Silva Gurgel
    • Laboratory of Pathology and Molecular BiologyGonçalo Moniz Research Center, Oswaldo Cruz Foundation
  • Renata Oliveira de Souza
    • Department of Oral Pathology, Laboratory of Oral Surgical Pathology, School of DentistryFederal University of Bahia
  • Caroline Brandi Schlaepfer Sales
    • Department of Oral Pathology, Laboratory of Oral Surgical Pathology, School of DentistryFederal University of Bahia
  • Alberto de Aguiar Pires Valença Neto
    • Laser Center, School of DentistryFederal University of Bahia
  • Eduardo Antônio Gonçalves Ramos
    • Laboratory of Pathology and Molecular BiologyGonçalo Moniz Research Center, Oswaldo Cruz Foundation
Original Paper

DOI: 10.1007/s10735-009-9238-x

Cite this article as:
dos Santos, J.N., Oliveira, G.Q.V., Gurgel, C.A.S. et al. J Mol Hist (2009) 40: 269. doi:10.1007/s10735-009-9238-x

Abstract

Keratocystic odontogenic tumor (KOT) is a benign cystic tumor that affects the jaw bones and may be associated with the nevoid basal cell carcinoma syndrome (NBCCS). Twenty-five cases diagnosed as KOT, including primary and recurrent tumors and those associated with NBCCS, were submitted to immunohistochemical study for analysis of cytokeratins (CKs) 7, 8, 10, 13, 14, 18 and 19. The results showed CK13 immunostained on the intermediate layers and upper cells. CK14 was expressed in all epithelial layers and in those areas where inflammation and subepithelial splits were present; this protein was preserved within the basal cells. CK 18 was expressed mainly in the basal layer, whereas CK19 was expressed mainly on the intermediate and superficial layers. The remaining CKs tested were not immuoreactive. The status of maturation of cytokeratin seems to be altered on KOTs, and this is not distinct when different tumors are compared.

Keywords

CytokeratinOdontogenic KeratocystsOdontogenic NeoplasmsImmunohistochemistry

Copyright information

© Springer Science+Business Media B.V. 2009