Journal of Molecular Histology

, Volume 37, Issue 5, pp 219–223

The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer

Original Paper

DOI: 10.1007/s10735-006-9042-9

Cite this article as:
Zeidler, M. & Kleer, C.G. J Mol Hist (2006) 37: 219. doi:10.1007/s10735-006-9042-9


The Polycomb group protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to tumorigenesis in multiple organs. In this review we summarize the current knowledge on the function of EZH2 in cancer, with special focus on breast cancer, and propose a link between EZH2, the homologous recombination pathway of DNA repair, and breast tumorigenesis.


EZH2Breast cancerDNA repairHomologous recombinationBiomarkerPrognosisPolycombRAD51RAD51 paralogsRAD51L1

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  1. 1.Department of Pathology and Comprehensive Cancer CenterUniversity of MichiganAnn ArborUSA