, Volume 37, Issue 5-7, pp 219-223
Date: 20 Jul 2006

The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer

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The Polycomb group protein EZH2 is a transcriptional repressor involved in controlling cellular memory and has been linked to tumorigenesis in multiple organs. In this review we summarize the current knowledge on the function of EZH2 in cancer, with special focus on breast cancer, and propose a link between EZH2, the homologous recombination pathway of DNA repair, and breast tumorigenesis.

Grant support: This work was supported in part by National Cancer Institute Grants K08CA090876 (CGK) and R01CA107469 (CGK), and Department of Defense grant DAMD17-01-1-490 (CGK).