Effects of malathion and cadmium on acetylcholinesterase activity and metallothionein levels in the fish Seriola dumerilli

  • J. Jebali
  • M. Banni
  • H. Guerbej
  • E. A. Almeida
  • A. Bannaoui
  • H. Boussetta
Research Article

DOI: 10.1007/s10695-006-0041-2

Cite this article as:
Jebali, J., Banni, M., Guerbej, H. et al. Fish Physiol Biochem (2006) 32: 93. doi:10.1007/s10695-006-0041-2

Abstract

The potential use of acetylcholinesterase (AChE) and metallothionein (MT) responses as biomarker of organophosphorous (OPs) and trace metal were assessed in fish Seriola dumerilli exposed to 0, 4, 6 mg/kg of malathion for 2, 7 and 13 days, and to 0, 50, 100, 250 μg/kg of Cd for 2 days. Brain AChE was significantly inhibited after 2 and 7 days of malathion exposure, in a dose–response manner, but no inhibition was observed after 13 days of exposure. When exposed to Cd for 2 days, S. dumerelli presented an increase in AChE activity at a concentration of 50  μg/kg, but a strong and dose-dependent AChE inhibition at 100 and 250 μg/kg. Cd treatment also caused a rapid increase in MTs concentration in liver, even at the lower concentration. Our experiments indicate that the measurement of hepatic MT concentration and brain AChE activity in S. dumerilli would be useful biomarkers of OP and Cd exposure and/or effects.

Keywords

Acetylcholinesterase Biomarkers Cadmium Malathion Metallothionein Metals Organophosphorous Seriola dumerilli 

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • J. Jebali
    • 1
  • M. Banni
    • 1
  • H. Guerbej
    • 2
  • E. A. Almeida
    • 3
  • A. Bannaoui
    • 4
  • H. Boussetta
    • 1
  1. 1.Laboratoire de Biochimie et de Toxicologie EnvironnementaleEcole Supérieure d’Horticulture et d’ElevageChott-MarièmTunisia
  2. 2.Centre de MonastirInstitut National des Sciences et Technologies de la Mer, INSTMMonastirTunisia
  3. 3.Departamento de Química e Ciências AmbientaisIBILCE-UNESPSão José do Rio PretoBrazil
  4. 4.Laboratoire Eau et Environnement, Faculté des sciencesUniversité Ibn IzhorAgadir

Personalised recommendations