Familial Cancer

, Volume 13, Issue 1, pp 45–56

Genetic variation at 8q24, family history of cancer, and upper gastrointestinal cancers in a Chinese population

  • Heather P. Tarleton
  • Shen-Chih Chang
  • Sungshim Lani Park
  • Lin Cai
  • Baoguo Ding
  • Na He
  • Shehnaz K. Hussain
  • Qingwu Jiang
  • Li-Na Mu
  • Jianyu Rao
  • Hua Wang
  • Nai-Chieh Y. You
  • Shun-Zhang Yu
  • Jin-Kou Zhao
  • Zuo-Feng Zhang
Original Article

DOI: 10.1007/s10689-013-9673-4

Cite this article as:
Tarleton, H.P., Chang, S., Park, S.L. et al. Familial Cancer (2014) 13: 45. doi:10.1007/s10689-013-9673-4

Abstract

Genetic variation at 8q24 is associated with prostate, bladder, breast, colorectal, thyroid, lung, ovarian, UADT, liver and stomach cancers. However, a role for variation at 8q24 in familial clustering of upper gastrointestinal cancers has not been studied. In order to explore potential inherited susceptibility, we analyzed epidemiologic data from a population-based case–control study of upper gastrointestinal cancers from Taixing, China. The study population includes 204 liver, 206 stomach, and 218 esophageal cancer cases and 415 controls. Associations between 8q24 rs1447295, rs16901979, rs6983267 and these cancers were stratified by family history of cancer. Odds ratios and 95 % confidence intervals were adjusted for potential confounders: age, sex, education, tobacco smoking, alcohol consumption, and BMI at interview. We also adjusted for hepatitis B and aflatoxin (liver cancer) and Helicobacter pylori (stomach cancer). In a dominant model, among those with a family history of cancer, rs1447295 was positively associated with liver cancer (ORadj 2.80; 95 % CI 1.15–6.80). Heterogeneity was observed (Pheterogeneity = 0.029) with rs6983267 and liver cancer, with positive association in the dominant model among those with a family history of cancer and positive association in the recessive model among those without a family history of cancer. When considered in a genetic risk score model, each additional 8q24 risk genotype increased the odds of liver cancer by two-fold among those with a family history of cancer (ORadj 2.00; 95 % CI 1.15–3.47). These findings suggest that inherited susceptibility to liver cancer may exist in the Taixing population and that variation at 8q24 might be a genetic component of that inherited susceptibility.

Keywords

Liver cancerStomach cancerEsophageal cancerHepatitis B8q24 SNPsFamily history of cancer

Abbreviations

AFB1

Plasma aflatoxin B1

SNP

Single nucleotide polymorphism

GI

Gastrointestinal

H. pylori

Helicobacter pylori

OR

Odds ratio

CI

Confidence interval

ROR

Ratio of odds ratios

GWAS

Genome wide association study

BMI

Body-mass-index

LD

Linkage disequilibrium

Supplementary material

10689_2013_9673_MOESM1_ESM.doc (66 kb)
Supplementary material 1 (DOC 66 kb)

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Heather P. Tarleton
    • 1
  • Shen-Chih Chang
    • 2
  • Sungshim Lani Park
    • 3
  • Lin Cai
    • 4
  • Baoguo Ding
    • 5
  • Na He
    • 6
  • Shehnaz K. Hussain
    • 2
    • 7
  • Qingwu Jiang
    • 6
  • Li-Na Mu
    • 8
  • Jianyu Rao
    • 2
  • Hua Wang
    • 9
  • Nai-Chieh Y. You
    • 2
  • Shun-Zhang Yu
    • 6
  • Jin-Kou Zhao
    • 10
  • Zuo-Feng Zhang
    • 2
    • 7
  1. 1.Department of Health and Human SciencesLoyola Marymount UniversityLos AngelesUSA
  2. 2.Department of Epidemiology, Fielding School of Public HealthUniversity of California, Los Angeles (UCLA)Los AngelesUSA
  3. 3.Epidemiology ProgramUniversity of Hawaii Cancer CenterHonoluluUSA
  4. 4.Department of Epidemiology, School of Public HealthFujian Medical UniversityFuzhouChina
  5. 5.Taixing City Center for Disease Control and Prevention (CDC)Taixing CityChina
  6. 6.School of Public HealthFudan UniversityShanghaiChina
  7. 7.Jonsson Comprehensive Cancer CenterUniversity of California, Los Angeles (UCLA)Los AngelesUSA
  8. 8.Department of Social and Preventive MedicineState University of New York (SUNY) at BuffaloBuffaloUSA
  9. 9.Monitoring and Evaluation UnitThe Global Fund to Fight AIDS, Tuberculosis and MalariaGenevaSwitzerland
  10. 10.Jiangsu Provincial Center for Disease Control and PreventionNanjingChina