, Volume 12, Issue 2, pp 143-144
Date: 10 May 2013

Foreword for “100 years of Lynch syndrome”

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Aldred Warthin, M.D., was a wonderful listener. When he asked his seamstress, in 1895, why she was so depressed, she told him that she would one day die of cancer. She said it had to be, because most members of her family died of cancer of the stomach, colon, or endometrium. Warthin pursued her pedigree rigorously, with as much genealogy, medical history, and pathology documentation as possible. The result was Family G, which has been updated several times since Warthin first reported it in 1913 [1]. In the exactly 100 years since this report, the clinical features have been refined. Several changes in terminology have occurred, from the original “cancer family syndrome”, which conveys no helpful information, to “hereditary nonpolyposis colorectal cancer” or HNPCC, which conveys enough information to be misleading, to “Lynch syndrome” or LS, which again conveys no information! This year also marks exactly 20 years since the real breakthroughs, the identification of the first locus for ...