Familial Cancer

, Volume 11, Issue 1, pp 7–12

The liver: another organ involved in Muir Torre syndrome?

  • F. Morando
  • M. Alaibac
  • A. Romano
  • M. Cavallin
  • S. Piano
  • M. Pizzi
  • C. Mescoli
  • P. Pilati
  • A. Gatta
  • P. Angeli
Article

DOI: 10.1007/s10689-011-9450-1

Cite this article as:
Morando, F., Alaibac, M., Romano, A. et al. Familial Cancer (2012) 11: 7. doi:10.1007/s10689-011-9450-1

Abstract

Muir Torre syndrome is a rare autosomal dominant cancer-predisposing syndrome characterized by the occurrence of sebaceous gland neoplasms and/or keratoacanthomas associated with visceral malignancies that belong to the spectrum of hereditary non polyposis colorectal cancer (HNPCC), i.e., tumors of gastrointestinal and genitourinary tracts. Hepatobiliary malignancy in association with Muir Torre syndrome has rarely been reported. Here, we describe a case of Muir Torre syndrome associated with an hepatocellular-carcinoma in a patient with a non-cirrhotic liver and an HNPCC-family with multiple cases of hepatocellular carcinoma.

Keywords

Hepatobiliary malignancyHepatocellular carcinomaLynch syndromeMuir-Torre syndromeMSH2 mutationSebaceous adenoma

Abbreviations

MTS

Muir-Torre syndrome

HNPCC

Hereditary non polyposis colorectal cancer

HCC

Hepatocellular carcinoma

FNAB

Fine needle aspiration biopsy

HOMA

Homeostasis model assessment

NAFLD

Non alcoholic fatty liver disease

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • F. Morando
    • 1
  • M. Alaibac
    • 2
  • A. Romano
    • 1
  • M. Cavallin
    • 1
  • S. Piano
    • 1
  • M. Pizzi
    • 3
  • C. Mescoli
    • 3
  • P. Pilati
    • 4
  • A. Gatta
    • 1
  • P. Angeli
    • 1
  1. 1.Department of Clinical and Experimental MedicineUniversity of PadovaPadovaItaly
  2. 2.Unit of DermatologyUniversity of PadovaPadovaItaly
  3. 3.Department of Diagnostic Medical Sciences and Special Therapies, Pathology UnitUniversity of PadovaPadovaItaly
  4. 4.Department of Oncological and Surgical SciencesUniversity of PadovaPadovaItaly