Familial Cancer

, Volume 10, Issue 2, pp 391–396

Familial gastric cancer: update for practice management

  • Giovanni Corso
  • Daniele Marrelli
  • Franco Roviello
Article

DOI: 10.1007/s10689-010-9410-1

Cite this article as:
Corso, G., Marrelli, D. & Roviello, F. Familial Cancer (2011) 10: 391. doi:10.1007/s10689-010-9410-1

Abstract

About 90% of gastric carcinoma presents a sporadic setting and only 10% shows a familial cluster; among this group, 1–3% are considered as hereditary syndromes, with a clear genetic pathway. The most important genetic mechanisms are associated with CDH1 germline mutations, causing the hereditary diffuse gastric cancer syndrome. Other inherited predispositions with gastric carcinoma are the hereditary nonpolyposis colorectal cancer, Li-Fraumeni and Peutz-Jeghers syndromes. In this brief update, we described these principal hereditary syndromes offering a simple management to physicians where are these diseases diagnosed.

Keywords

E-cadherinMismatch repair genesTP53STK11

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Giovanni Corso
    • 1
    • 2
    • 3
  • Daniele Marrelli
    • 1
    • 2
  • Franco Roviello
    • 1
    • 2
  1. 1.Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, Translational Research LaboratoryUniversity of SienaSienaItaly
  2. 2.Istituto Toscano Tumori (ITT)FlorenceItaly
  3. 3.Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP)PortoPortugal