Familial Cancer

, Volume 8, Issue 4, pp 299–305

The relationship between knowledge of family history and cancer characteristics at diagnosis in women newly-diagnosed with invasive breast cancer

  • Marijana Lijovic
  • Susan R. Davis
  • Pam Fradkin
  • Jo Bradbury
  • Maria La China
  • Max Schwarz
  • Rory Wolfe
  • Helen Farrugia
  • Robin J. Bell
Article

DOI: 10.1007/s10689-009-9236-x

Cite this article as:
Lijovic, M., Davis, S.R., Fradkin, P. et al. Familial Cancer (2009) 8: 299. doi:10.1007/s10689-009-9236-x

Abstract

Aim To document the prevalence of family history of breast cancer (BC) amongst women newly-diagnosed with invasive BC and to explore the relationship between family history and cancer size and stage. Methods A cross-sectional analysis was conducted on baseline questionnaire data from a cohort study of 1,684 women diagnosed with invasive BC within the previous 12 months and recruited between 2004 and 2006 in Victoria, Australia. Results Women with affected first degree relative(s) were more likely to have a smaller BC (odds ratio for ≤10 mm 1.74, 95% CI: 1.32–2.29) and stage I BC (odds ratio 1.31, 95% CI: 1.01–1.70) at diagnosis than women with no affected relatives. There was no significant difference in BC size and stage between women with only affected second degree relatives and women with no affected relatives. Conclusions Women with a first degree relative with BC had smaller, earlier stage cancers at diagnosis, possibly reflecting more diligent use of breast screening amongst women who considered themselves at increased risk of developing the disease.

Keywords

Breast cancerBreast screeningDiagnosisFamilialFamily historyMammographySizeStage

Abbreviations

BC

Breast cancer

CI

Confidence interval

EQ

Enrolment questionnaire

OR

Odds ratio

TNM

Tumour node metastasis

VCR

Victorian cancer registry

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Marijana Lijovic
    • 1
  • Susan R. Davis
    • 1
  • Pam Fradkin
    • 1
  • Jo Bradbury
    • 1
  • Maria La China
    • 1
  • Max Schwarz
    • 2
    • 3
  • Rory Wolfe
    • 4
  • Helen Farrugia
    • 5
  • Robin J. Bell
    • 1
  1. 1.Women’s Health Program, Department of MedicineMonash University, Alfred HospitalPrahranAustralia
  2. 2.Department of Medicine, Central Clinical SchoolMonash University, Alfred HospitalPrahranAustralia
  3. 3.Bayside HealthPrahranAustralia
  4. 4.Department of Epidemiology and Preventive MedicineMonash UniversityMelbourneAustralia
  5. 5.Victorian Cancer RegistryThe Cancer Council VictoriaCarltonAustralia