Familial Cancer

, Volume 8, Issue 2, pp 167–171

Concordant colon tumors in monozygotic twins previously treated for prostate cancer

  • Arnoud Templeton
  • Giancarlo Marra
  • Emanuele Valtorta
  • Karl Heinimann
  • Hansjakob Müller
  • Dieter Köberle
  • Silke Gillessen
Article

DOI: 10.1007/s10689-008-9222-8

Cite this article as:
Templeton, A., Marra, G., Valtorta, E. et al. Familial Cancer (2009) 8: 167. doi:10.1007/s10689-008-9222-8

Abstract

This report describes the quasi-simultaneous occurrence of colon cancers in monozygotic twin brothers (age 63 years) who had undergone androgen deprivation therapy for prostate cancers 4 years earlier. Concordance among male twins for both of these cancers has never been reported. Although the family history suggested possible genetic predispositions to both cancers, the twins have no evidence of the genetic alterations associated with hereditary colorectal tumors. We explore the possibility that colorectal tumorigenesis in these twins was fuelled by a combination of genetic and iatrogenic factors, in particular the androgen deprivation therapy used to treat their prostate cancers.

Keywords

Androgen deprivationColon cancerMonozygotic twinsProstate cancerWnt signalling

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Arnoud Templeton
    • 1
  • Giancarlo Marra
    • 2
  • Emanuele Valtorta
    • 2
  • Karl Heinimann
    • 3
  • Hansjakob Müller
    • 3
  • Dieter Köberle
    • 1
  • Silke Gillessen
    • 1
  1. 1.Department of Medical OncologyKantonsspitalSt. GallenSwitzerland
  2. 2.Institute of Molecular Cancer ResearchUniversity of ZurichZurichSwitzerland
  3. 3.Division of Medical Genetics UKBB/DKBWUniversity of BaselBaselSwitzerland