Familial Cancer

, Volume 6, Issue 1, pp 141–145

A case of Muir-Torre syndrome associated with mucinous hepatic cholangiocarcinoma and a novel germline mutation of the MSH2 gene

  • M. Vernez
  • P. Hutter
  • C. Monnerat
  • N. Halkic
  • O. Gugerli
  • H. Bouzourene
Case Report

DOI: 10.1007/s10689-006-9105-9

Cite this article as:
Vernez, M., Hutter, P., Monnerat, C. et al. Familial Cancer (2007) 6: 141. doi:10.1007/s10689-006-9105-9


Muir-Torre syndrome (MTS) is a rare cancer-predisposing syndrome that is autosomal dominantly inherited and characterized by the development of sebaceous skin lesions (adenomas, epitheliomas, basaliomas and carcinomas). These lesions are typically associated with tumors that belong to the spectrum of hereditary nonpolyposis colorectal cancer (HNPCC) (i.e. tumors of the colorectum, endometrium, stomach or ovary). Biliary malignancy in association with MTS has only rarely been reported. We report a case of Muir-Torre syndrome associated with intrahepatic cholangiocarcinoma, a location not previously described, and associated with a novel missense mutation of the MSH2 gene (c.2026T > C), predicted to disrupt the function of the gene.


CholangiocarcinomaHNPCCMuir-Torre syndromeMSH2Sebaceous epithelioma



carcino embryonic antigen


hereditary non polyposis colon cancer


Muir-Torre syndrome


magnetic resonance imaging


microsatellite instability

Copyright information

© Springer Science + Business Media B.V. 2006

Authors and Affiliations

  • M. Vernez
    • 1
  • P. Hutter
    • 2
  • C. Monnerat
    • 3
  • N. Halkic
    • 4
  • O. Gugerli
    • 5
  • H. Bouzourene
    • 1
  1. 1.Department of Pathology, Institut Universitaire de PathologieLausanne University HospitalLausanneSwitzerland
  2. 2.Division of Medical GeneticsICHVSionSwitzerland
  3. 3.Department of GeneticsLausanne University HospitalLausanneSwitzerland
  4. 4.Department of SurgeryLausanne University HospitalLausanneSwitzerland
  5. 5.Department of DermatologyLausanne University HospitalLausanneSwitzerland