Familial Cancer

, Volume 5, Issue 4, pp 359–368

Screening behavior in women at increased familial risk for breast cancer

  • Yoland C. Antill
  • John Reynolds
  • Mary Anne Young
  •  ˙ Judy A. Kirk
  • Katherine M. Tucker
  • Tarli L. Bogtstra
  •  ˙ Shirley S. Wong
  •  ˙ Tracy E. Dudding
  • Juliana L. Di Iulio
  • Kelly-Anne Phillips
Original Paper

DOI: 10.1007/s10689-006-0006-8

Cite this article as:
Antill, Y., Reynolds, J., Young, M.A. et al. Familial Cancer (2006) 5: 359. doi:10.1007/s10689-006-0006-8

Abstract

This multicenter study examined the adherence of high-risk women to screening recommendations for breast and ovarian cancer following consultation at a familial cancer clinic (FCC). Self-report questionnaires assessing recall of screening advice, tests undertaken, risk perception, anxiety (Impact of Events Scale) and demographics were mailed to 396 consecutive eligible women who had attended one of six FCCs a median of 3.6 years prior. Family history, genetic test results and screening recommendations were abstracted from medical records. 182/266 (68.4%) women responded with 130 lost to follow-up. The proportions of women undertaking at least the recommended frequency of screening tests were: breast␣self examination (BSE) 50.4%, clinical breast examination (CBE) 66.0%, mammography 82.2%, transvaginal ultrasound (TVUS) 70.0%, CA125 84.0%. Factors associated with adherence to screening were: higher anxiety for BSE and CBE, being BRCA1/2 positive for CBE, older age, method of arrangement and having at least one affected first degree relative for mammography. Factors significantly associated with over-adherence were higher scores for anxiety for BSE and CBE and younger age (< 40 years) for TVUS. Between 41.3% (BSE) and 57.6% (CBE) of women incorrectly recalled their screening recommendations. A substantial minority of high-risk women do not adhere to screening advice. Strategies to improve the accuracy of recall of recommendations and the uptake of recommended screening are required.

Keywords

BRCA1BRCA2Breast neoplasmOvarian neoplasmScreening

Abbreviations

FCC

Familial Cancer Centre

BSE

Breast Self Examination

CBE

Clinical Breast Examination

TVUS

Transvaginal Ultrasound

BC

Breast Cancer

OC

Ovarian Cancer

CIN

Carcinoma Intraepithelial Neoplasia

CI

Confidence Interval

Mod

Moderate

AUD

Australian Dollars

No.

Number

Mammo

Mammogram

n/a

not applicable

Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • Yoland C. Antill
    • 1
    • 3
  • John Reynolds
    • 2
  • Mary Anne Young
    • 1
  •  ˙ Judy A. Kirk
    • 4
  • Katherine M. Tucker
    • 5
  • Tarli L. Bogtstra
    • 6
  •  ˙ Shirley S. Wong
    • 7
  •  ˙ Tracy E. Dudding
    • 8
  • Juliana L. Di Iulio
    • 2
  • Kelly-Anne Phillips
    • 1
    • 3
  1. 1.Department of Hematology and Medical OncologyPeter MacCallum Cancer CentreMelbourneAustralia
  2. 2.Statistical Centre, Peter MacCallum Cancer Centre, Locked Bag1, A'Beckett StMelbourneAustralia
  3. 3.University of MelbourneMelbourneAustralia
  4. 4.Westmead HospitalWestmeadAustralia
  5. 5.Prince of Wales HospitalRandwickAustralia
  6. 6.Monash Medical CentreClaytonAustralia
  7. 7.Royal Melbourne HospitalParkvilleAustralia
  8. 8.Hunter GeneticsNewCastleAustralia